Ondo

Researchers are evaluating the ADHINCRA Program, a package of evidence-based interventions aimed at improving the control of hypertension among adults aged 18 to 70 in Africa. The program targets factors related to patients, healthcare providers, and health systems to help reduce risks of cardiovascular disease, stroke, and kidney disease. This interventional study is sponsored by Johns Hopkins University and focuses on managing high blood pressure using a nurse-led approach. The ADHINCRA Program includes home blood pressure monitoring, a mobile health application, nurse-led lifestyle counseling, and treatment using a simplified hypertension control protocol. Participants are divided into four cohorts starting the program at staggered intervals immediately, and 3, 6, and 9 months thereafter. All cohorts receive the same intervention to assess its effectiveness and implementation over time. Participants will be monitored for blood pressure control at baseline and at 12 and 24 months after starting the program. Assessments include systolic and diastolic blood pressure measurements, medication adherence via the Hill-Bone Medication Adherence Scale, and evaluation of how well the program is adopted and maintained at clinical sites. Researchers will also compare the cost of this intervention to usual care. The study is planned to end in September 2028, with ongoing safety and adherence monitoring throughout.

Neglected tropical diseases NTDs affect over one billion people worldwide, especially in remote and underserved communities. This research evaluates strategies to improve access to preventive chemotherapy among mobile and migrant populations MMPs in Nigeria, who often miss treatment during mass drug administration MDA campaigns. The study focuses on understanding migration patterns and social networks to enhance treatment reach and coverage in these hard-to-reach groups. The study involves a multi-site approach across 15 communities in three Nigerian states with pastoralist, fishing, and agrarian populations. It includes four phases assessing baseline NTD burden and treatment coverage, mapping migration and social networks, co-developing tailored delivery strategies with communities, and implementing and evaluating the modified mass administration of medicines MAM campaign. The new approach adapts timing, locations, and supportive livelihood services to better fit MMPs mobility and needs. Participants will provide biological samples and participate in surveys, interviews, and workshops to inform and assess the intervention. Researchers will measure treatment reach, coverage, compliance, and acceptability, as well as implementation outcomes such as adoption, fidelity, and sustainability. The study aims to generate evidence on the feasibility and impact of the community-informed delivery model to support inclusive NTD programming in Nigeria by the end of 2027.