Addressing Hypertension Care in Africa (ADHINCRA): Study protocol for a cluster-randomized controlled pilot trial.
Yvonne Commodore-Mensah, Fred Stephen Sarfo, Ruth-Alma Turkson-Ocran...
https://pubmed.ncbi.nlm.nih.gov/36592818Actively Recruiting
Phase Not Applicable
Age: 18Years - 70Years
All Genders
ID06986590
Addressing Hypertension Care in Africa (ADHINCRA) Program
Led by Johns Hopkins University · Updated on 2026-01-14
800
Participants Needed
17
Research Sites
26 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the ADHINCRA Program, a package of evidence-based interventions aimed at improving the control of hypertension among adults aged 18 to 70 in Africa. The program targets factors related to patients, healthcare providers, and health systems to help reduce risks of cardiovascular disease, stroke, and kidney disease. This interventional study is sponsored by Johns Hopkins University and focuses on managing high blood pressure using a nurse-led approach. The ADHINCRA Program includes home blood pressure monitoring, a mobile health application, nurse-led lifestyle counseling, and treatment using a simplified hypertension control protocol. Participants are divided into four cohorts starting the program at staggered intervals: immediately, and 3, 6, and 9 months thereafter. All cohorts receive the same intervention to assess its effectiveness and implementation over time. Participants will be monitored for blood pressure control at baseline and at 12 and 24 months after starting the program. Assessments include systolic and diastolic blood pressure measurements, medication adherence via the Hill-Bone Medication Adherence Scale, and evaluation of how well the program is adopted and maintained at clinical sites. Researchers will also compare the cost of this intervention to usual care. The study is planned to end in September 2028, with ongoing safety and adherence monitoring throughout.
CONDITIONS
Brief Title
Addressing Hypertension Care in Africa Program
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- Aged 18 -70 years.
- Diagnosis of hypertension with systolic blood pressure 6450 mmHg at the most recent clinic visit without diabetes.
- Hypertension treatment naive or on monotherapy.
- Receives primary care at one of the participating sites.
- Willing and able to provide informed consent in English, Twi, Dagbani, Ewe, Hausa, or Yoruba.
- Owns a smartphone (Android or iOS).
You will not qualify if you...
- Age under 18 years or over 70 years.
- Severely elevated blood pressure (65180/110 mmHg).
- Diagnosis of stroke, coronary artery disease, or kidney disease.
- Diagnosis of end-stage renal disease (ESRD) treated with dialysis.
- Serious medical condition limiting life expectancy or requiring active management (e.g., cancer).
- Cognitive impairment or other conditions preventing study participation.
- Pregnant or currently nursing a child.
- Unwilling to provide informed consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Outpatient Treatment
Duration - Up to 12 months
Participants take part in the ADHINCRA Program, a nurse-led intervention that includes home blood pressure monitoring, use of a mobile health app, lifestyle counselling, and a simplified hypertension treatment protocol to manage blood pressure.
Visits occur depending on cohort start time with follow-up assessments at baseline, 12 months, and 24 months post-randomization
Trial Site Locations
Total: 17 locations
1
Johns Hopkins University
Baltimore, Maryland, United States, 21205
Active, Not Recruiting
2
Dominase SDA Hospital
Bekwai, Ashanti Region, Ghana
Not Yet Recruiting
3
Kumasi South Hospital
Kumasi, Ashanti Region, Ghana
Not Yet Recruiting
4
Manhyia Government Hospital
Kumasi, Ashanti Region, Ghana
Actively Recruiting
5
Tafo Government Hospital
Tafo, Ashanti Region, Ghana
Not Yet Recruiting
6
Berekum Holy Family Hospital
Berekum, Bono, Ghana
Not Yet Recruiting
7
St. John of God Catholic Hospital
Duayaw Nkwanta, Bono, Ghana
Actively Recruiting
8
Northern Regional Hospital
Tamale, Northern Region, Ghana
Actively Recruiting
9
Tamale Teaching Hospital
Tamale, Northern Region, Ghana
Not Yet Recruiting
10
Ho Municipal Hospital
Ho, Volta Region, Ghana
Not Yet Recruiting
11
South Tongu District Hospital
Sogakope, Volta Region, Ghana
Not Yet Recruiting
12
Akure South Hospital
Akure, Ondo State, Nigeria
Actively Recruiting
13
Akoko North East
Ondo, Ondo State, Nigeria
Not Yet Recruiting
14
Akoko North West
Ondo, Ondo State, Nigeria
Not Yet Recruiting
15
Akoko South East
Ondo, Ondo State, Nigeria
Not Yet Recruiting
16
Akoko South West
Ondo, Ondo State, Nigeria
Not Yet Recruiting
17
Owo General Hospital
Owo, Ondo State, Nigeria
Not Yet Recruiting
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Research Team
Y
Yvonne Commodore-Mensah, PhD, MHS, RN
R
Research Program Manager
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
4
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