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Researchers are investigating whether a treat-to-target strategy that includes structured imaging assessments improves patient outcomes in psoriatic arthritis compared to a conventional treat-to-target approach. The study focuses on sustained remission, defined as very low disease activity at 16, 20, and 24 months. This two-arm, parallel-group study randomizes patients to either conventional clinical assessments or additional imaging assessments using ultrasound and MRI to guide treatment decisions. Participants receive treatment following European recommendations, with the conventional arm targeting disease activity based on clinical measures such as DAPSA remission, enthesitis, and psoriasis body surface area. The imaging-informed arm adds ultrasound assessments of joints, tendons, and entheses at every visit, plus MRI of the spine and sacroiliac joints at baseline and one year. Imaging results influence treatment progression, including advancing to biologic disease-modifying drugs if inflammation is detected. During the 24-month follow-up, patients undergo clinical and imaging assessments, including joint counts, enthesitis indices, and skin evaluations. Researchers measure disease activity, inflammation, health-related quality of life, and adverse events throughout the study. The primary outcome is sustained remission, while secondary outcomes include various disease activity scores and safety monitoring. The study aims to provide insights into the benefits of incorporating imaging in psoriatic arthritis management.

Researchers are exploring the effects of intraarticular corticosteroid injections, saline injections, and a multimodal occupational therapy intervention in people with inflammatory carpometacarpal-1 osteoarthritis CMC-1 OA. This trial, known as the PICASSO trial, aims to compare these pharmacological and non-pharmacological treatments head-to-head for efficacy and safety, focusing on patients with painful and inflammatory CMC-1 OA. The study will also investigate predictors of treatment effects and explore long-term safety and whether the occupational therapy can prevent or stop joint subluxation. Participants will be randomly assigned to one of three groups a corticosteroid injection group receiving a single ultrasound-guided injection of triamcinolone acetonide at baseline with a possible repeat at 12 weeks if pain and inflammation persist a placebo group receiving a saline injection under the same conditions or an occupational therapy group involving patient education, hand exercises, training using the Happy Hands app, and use of day and night orthosis over a 12-week period. Dosage may be adjusted if resistance is noted during injections. During the study, participants will be assessed for pain during thumb activities at 4 and 12 weeks as the primary outcome. Additional evaluations include pain at rest and during activities in finger joints, hand function indexes, disease activity reports, joint tenderness, grip strength, medication use, ultrasound assessments, and safety monitoring up to 104 weeks. The study uses ultrasound guidance, questionnaires, and clinical exams to monitor disease progression and treatment effects, with follow-ups continuing for up to two years.

Researchers are studying predictors of clinical course and treatment response in patients receiving Dialectical Behaviour Therapy DBT in Norway. The study focuses on individuals with repeated self-harm behavior and borderline personality disorder, aiming to understand which patient characteristics and treatment factors influence outcomes such as symptom levels, functioning, problem behaviors, and emergency service use. This research is a collaboration between The National Centre for Suicide Research and Prevention and clinical units with DBT programs. Participants receive either DBT adapted for adolescents DBT-A over 20 weeks or the standard DBT for adults lasting 52 weeks. DBT-A includes weekly individual therapy, multifamily skills training, family therapy as needed, and telephone coaching. Standard DBT involves weekly individual therapy, weekly skills training, and telephone coaching outside sessions. Assessments occur before treatment, during treatment at several points, at treatment end, and follow-up, using interviews and patient self-reports. During the study, patients provide self-report data electronically on tablets and via a mobile app several times daily. Therapists enter interview and rating data into the database. The main outcomes measured include self-harm behavior, suicidal ideation, depressive symptoms, borderline symptoms, and hopelessness at various intervals. The study collects data over time to evaluate clinical changes and treatment impact, with participation lasting through the treatment and follow-up periods.

Researchers are evaluating how adults with schizophrenia, other non-affective psychotic disorders, or psychosis risk syndromes experience a new psychotherapeutic approach called Seven-Step Phenomenological Psychotherapy for Self-Disorder SSPP-SD. This pilot study focuses on understanding participants subjective experiences with the treatment, including whether they found it helpful, how it may have changed their sense of self and relationships, and it uses a qualitative, phenomenological design to gather this information. The treatment involves 14 individual psychotherapy sessions over 7 to 10 weeks. The SSPP-SD model emphasizes exploring anomalous self-experiences, understanding their meanings and behaviors, psychoeducation, and collaboratively seeking new understandings related to these experiences. The first step includes a semi-structured interview using the Examination of Anomalous Self-Experience EASE. Two experienced therapists trained in this model provide all therapy sessions. Participants will be interviewed after treatment to discuss their therapy experiences, including positive and negative aspects. They will also complete questionnaires assessing symptoms, functioning, quality of life, and satisfaction before and after treatment. Researchers will monitor therapist adherence to the treatment manual and gather therapist feedback. The primary outcome is participants experience of the SSPP-SD model, assessed up to 12 weeks post-enrollment. The study lasts through treatment and follow-up assessments.

Researchers are evaluating treatments for displaced olecranon fractures in patients aged 75 years or older. These fractures affect the elbows extensor mechanism, and surgical options like tension band wiring and plate fixation are common but come with high complication and reoperation rates, especially in elderly patients. The study aims to compare operative treatment with non-operative care to determine the best approach for this population. Patients in the study will be randomly assigned to receive either surgery or non-operative treatment. Those in the surgical group will undergo tension band wiring or plate fixation using an anatomical precontoured plate, performed by experienced surgeons according to Orthopedic Trauma Association principles. Patients in the non-operative group will be offered a plaster cast or back-slab for 1 to 2 weeks to relieve pain, which is then removed after 7 to 14 days. During the trial, participants will be monitored through various assessments over 52 weeks, including measuring elbow function with the Oxford Elbow Score, range of motion, elbow extension strength, and satisfaction. Researchers will also track complications and any reoperations throughout the study period. The total follow-up time for each participant is one year, allowing thorough evaluation of treatment outcomes and safety.