Faisalabad

This research aims to compare the effectiveness of Muscle Energy Techniques (MET) and Neck Calliet Exercises in treating mechanical neck pain and related disability caused by trigger points in the trapezius muscle among female nurses aged 18 to 30. Neck pain is common in nurses due to repetitive strain, prolonged standing, and poor work postures, with trapezius trigger points limiting neck movement and increasing disability. The trial is a single-blinded, randomized clinical study involving 38 female nurses with mechanical neck pain and active trapezius trigger points. Participants were randomly assigned to two groups: one group received Muscle Energy Techniques targeting the upper trapezius trigger points, including post-isometric relaxation and stretching, and the other group performed supervised Neck Calliet Exercises focusing on cervical flexion, extension, rotation, and lateral flexion. Both groups also received Transcutaneous Electrical Nerve Stimulation (TENS) therapy as baseline treatment. Treatments were given three times per week for four weeks. Throughout the study, pain intensity and functional disability were assessed at the start and after four weeks. Researchers monitored neck pain levels, cervical range of motion, and disability outcomes. The study focused on evaluating the changes in pain and disability to understand how each therapy affects mechanical neck pain caused by trapezius trigger points in nurses.

Non-specific neck pain is a common musculoskeletal condition that causes discomfort, reduced craniovertebral angle, and disability. Researchers are evaluating the combined effects of Sustained Natural Apophyseal Glides (SNAGs) and Cognitive Behavioral Therapy (CBT) on pain, posture, and function in patients aged 18 to 28 years. This randomized controlled trial aims to explore both physical and psychological treatment approaches to improve long-term outcomes for those with non-specific neck pain. Participants will be randomly divided into two groups. Both groups receive a 5-minute hot pack application and 5 minutes of myofascial release to relax the cervical muscles, followed by 10 minutes of SNAGs therapy. Group A will then have a 20-minute CBT session focusing on pain management, posture, and ergonomics, while Group B will perform 20 minutes of cervical stabilization exercises involving neurodevelopmental stages, isometric training, and functional exercises. Treatments are provided twice weekly for four weeks. During the study, pain intensity, craniovertebral angle, and disability will be assessed at the start and after four weeks using standardized tools. Data will be analyzed to compare improvements within and between groups. This research also includes monitoring of posture and function, aiming to provide a comprehensive understanding of how combined physical and psychological therapies may benefit people with non-specific neck pain.

Researchers are evaluating a triple-pill combination therapy that includes empagliflozin, linagliptin, and metformin for managing advanced type 2 diabetes mellitus (T2DM). This phase 4 study aims to assess the treatment's impact on blood sugar control, measured by changes in HbA1c levels, as well as patient compliance, weight management, quality of life, satisfaction with diabetic treatment, and the frequency of low blood sugar events. The study focuses on simplifying diabetes care by combining three oral anti-diabetic drugs into a single pill to improve adherence and outcomes. The intervention involves administering a fixed-dose single pill that combines the three drugs to participants who have had type 2 diabetes for at least six months and are already on two or more anti-diabetic medications. The study evaluates this poly-pill approach to see if it can reduce pill burden, improve metabolic control, and safely manage diabetes. The research also considers the benefits for low- and middle-income countries by offering a potentially more affordable and easier-to-manage treatment option. Participants will be monitored over a period of three and six months to measure changes in HbA1c levels as the primary outcome. The study includes evaluations of patient compliance, weight, quality of life, and treatment satisfaction, along with tracking hypoglycemic events. Safety assessments and adherence monitoring will be part of the follow-up to ensure the combination therapy is well tolerated. The total participation duration covers these key outcome measurement time points to assess both short- and mid-term effects of the triple combination therapy.

Researchers are evaluating the effectiveness of teletherapy compared to traditional in-person third-wave cognitive behavioral therapy (CBT) for treating generalized anxiety disorder (GAD) in adults aged 18 to 45 years in Pakistan. The study aims to determine whether teletherapy is as effective as face-to-face therapy in reducing anxiety symptoms and stress. It also explores how factors like therapeutic alliance, treatment adherence, and social support might influence treatment outcomes differently between the two delivery methods. Participants will be randomly assigned to one of two groups: a teletherapy group receiving twelve weekly 40-minute sessions via secure video conferencing, or an in-person group attending twelve weekly 40-minute face-to-face sessions. Both groups will receive the same third-wave CBT content, which includes mindfulness, behavioral activation, and exposure therapy. The intervention lasts eight weeks, and the treatment protocol is standardized across groups. During the study, participants will complete assessments at baseline, after the intervention, and at follow-up using validated scales such as the Hamilton Anxiety Rating Scale (HAM-A), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9). Researchers will also evaluate perceived stress, work and social adjustment, and therapeutic alliance. The study is conducted at Allied Hospital II, Faisalabad, and aims to improve mental health access in resource-limited settings by testing teletherapy as a potential alternative to in-person care.