Faisalabad

Researchers are evaluating the effectiveness of two drugs, adrenaline and dopamine, for treating fluid refractory septic shock in children. This serious condition requires urgent treatment, and the study aims to compare how well these drugs work by measuring heart rate, Glasgow Coma Scale GCS, capillary refill time, peripheral pulse, urine output, and systolic blood pressure. This randomized control trial focuses on children diagnosed with this type of septic shock to determine which drug better corrects these vital parameters over time. Participants will be randomly assigned to receive either adrenaline at a dose of 0.1-0.3 micrograms per kilogram per minute or dopamine at a dose of 10-20 micrograms per kilogram per minute once diagnosed with fluid refractory septic shock. These drugs will be administered continuously during the trial period, and the treatment groups include Group A adrenaline and Group B dopamine. The study does not involve any masking or blinding, and treatments are given based on random assignment. During the study, researchers will monitor participants closely for changes in blood pressure, pulse, capillary refill time, urine output, and GCS over a 6-hour period. Additional assessments include the Sequential Organ Failure Assessment SOFA score at 6 hours to evaluate organ function. The trial will enroll children aged 1 month to 12 years, and their vital signs and clinical status will be tracked to compare the effects of the two drugs. The participation duration covers the critical early hours of treatment when fluid refractory septic shock is addressed.

Researchers are studying how sensory-motor integration exercises affect sensory modulation and motor skills in children aged 9 to 11 years diagnosed with Autism Spectrum Disorder ASD. This trial aims to address challenges in sensory processing and motor coordination that impact daily activities and behavior in children with ASD. The study uses a quasi-experimental design with assessments before and after the intervention for both treatment and control groups. Participants will be randomly assigned to either a treatment group receiving 12 sessions of sensory-motor integration exercises based on Ayres Sensory Integration principles or a control group receiving standard care. The exercises include activities that stimulate tactile, proprioceptive, and vestibular senses, such as pressing play dough, crawling, balancing, jumping, swinging, and obstacle navigation. Sessions last about 45 minutes and are held three times a week for four weeks, with a focus on individualized, child-centered therapy. During the study, children will be evaluated using the Test of Gross Motor Development TGMD-2 and the Sensory Modulation Assessment Tool to measure changes in sensory responsiveness and motor skills. Data will be analyzed to compare improvements between the groups. The trial is sponsored by Riphah International University and seeks to support sensory-motor strategies in rehabilitation programs, especially in low-resource settings.

Wrist joint overuse syndrome is a challenging musculoskeletal condition affecting bones, muscles, tendons, peripheral nerves, and blood vessels, commonly involving the back, neck, and upper limbs. This research evaluates and compares two approaches of myofascial release therapy3-dimensional articular and soft tissue methodsin adults aged 20 to 55 diagnosed with this syndrome. The diagnosis is based on tenderness in intrinsic wrist muscles and pain in the radial ligament. Participants are randomly divided into two groups of 23 each. Both groups receive a 15-minute hot pack as baseline treatment. Group A undergoes 3-dimensional articular fascial release, while Group B receives 3-dimensional soft tissue release. Treatments occur three times per week for three weeks. After therapy sessions, both groups perform wrist range of motion exercises including wrist flexion, extension, and radial and ulnar deviation, with five repetitions each. Participants will be assessed using pain scales like the Numeric Pain Rating Scale NPRS, functional disability evaluations such as the Disabilities of Arm, Shoulder, and Hand DASH, and the Patient Rated Wrist Evaluation PRWE specific to wrist function. Range of motion is measured with a goniometer. Data analysis will be conducted with SPSS software. The primary outcomes measured are pain intensity and range of motion over three weeks, with functional disability as a secondary outcome.

Stroke is a leading cause of long-term neurological disability worldwide, often causing significant upper limb motor problems that affect daily function and quality of life. This research aims to compare two ways of delivering Constraint-Induced Movement Therapy CIMT, a rehabilitation method that encourages use of the affected arm by restricting the unaffected one and focusing on specific, intense training tasks. The study will evaluate these methods in people who have had a stroke within the past six months. Participants will be randomly assigned to one of two groups one receiving CIMT in a clinical setting with direct supervision, and the other receiving the same therapy through a structured online telerehabilitation platform, also supervised. Both groups will undergo the intervention for eight weeks, with treatments including restraining the unaffected limb for 5-6 hours daily and performing targeted exercises like reaching, grasping, and lifting. Throughout the study, researchers will assess participants upper limb function and muscle spasticity using tests such as the Action Research Arm Test and the Wolf Motor Function Test at the start and after eight weeks of treatment. The study will monitor progress and functional improvements to understand how well each delivery method supports motor recovery after stroke.

This research aims to compare two surgical methods for treating palpable undescended testis in male children under 10 years old. The study focuses on evaluating operative time, cosmetic outcomes, and post-operative complications to determine differences between the approaches. It is a randomized, interventional trial conducted at Children Hospital Faisalabad to assess these surgical techniques in young patients. Participants are randomly assigned to one of two groups. One group undergoes single incision scrotal orchidopexy, where the surgery is done through a single scrotal cut. The other group receives the standard two incision inguinal orchidopexy, involving separate cuts in the inguinal and scrotal areas. Both procedures are conventional orchidopexies aimed at repositioning the testis. During the study, children will be monitored for post-operative complications from 24 hours up to one month after surgery. Cosmetic outcomes will be evaluated two weeks post-surgery. The study includes follow-up visits to assess healing and surgical results, and all data will be collected to compare the two methods. Participation involves surgery, follow-up assessments, and monitoring for safety and effectiveness throughout the study period.

Musculoskeletal disorders such as mechanical neck pain are common among nurses due to repetitive strain and poor work postures. This trial evaluates the effectiveness of Muscle Energy Techniques MET compared to Neck Calliet Exercises in managing neck pain and disability caused by trapezius muscle trigger points in female nurses aged 18 to 30. The study aims to reduce pain, improve neck movement, and lessen disability associated with trigger points in this population. Participants are randomly assigned to one of two groups one receiving MET and the other performing Neck Calliet Exercises, both combined with baseline Transcutaneous Electrical Nerve Stimulation TENS therapy. Treatments are delivered three times per week for four weeks. MET involves post-isometric relaxation and stretching targeting trapezius trigger points, while Neck Calliet Exercises focus on cervical movements including flexion, extension, rotation, and lateral flexion. During the study, pain intensity, functional disability, and cervical range of motion are measured at the start and after four weeks of treatment. The trial includes regular assessments to monitor these outcomes. Participants attend sessions three times weekly and follow prescribed exercises or therapy under supervision. The study emphasizes tracking improvements in neck pain and movement over the treatment period to compare the two approaches.

This research aims to evaluate the effect of pelvic stability training on lower limb motor function in adults who have experienced a subacute stroke. The study focuses on individuals aged 40 to 60 years who have had their first stroke episode, either hemorrhagic or ischemic. Hemiparesis, involving weakness in the lower limbs and pelvic instability, is a common consequence of stroke, and this trial seeks to understand how targeted training might impact recovery. Participants are randomly assigned to one of two groups. One group receives pelvic stability training combined with lower limb passive stretching and neuromuscular electrical stimulation NMES. The other group receives only lower limb passive stretching and NMES. Both interventions are administered three times a week on alternate days over an eight-week period. During the study, data are collected at baseline and after eight weeks to measure pelvic tilt, motor function of the lower extremities using the Fugl-Meyer assessment, and gait cadence. These assessments help evaluate changes in motor function and pelvic stability. The trial uses statistical analysis to compare results between groups to understand the trainings impact on stroke recovery.

This research aims to compare two different exercise approaches focused on the hip or the knee to see their effects on foot arch height, balance, and leg muscle strength in adults aged 25 to 40 with flexible flat feet. The study will randomly assign participants to either a hip-based or knee-based exercise group to find out which method better improves foot stability and function. Participants will take part in a 6-week exercise program. One group will do hip-focused strengthening and stretching, including clamshell exercises and iliopsoas stretching, combined with hot pack application and foot intrinsic exercises. The other group will perform knee isometric exercises with hamstring stretching along with the same hot pack and foot exercises. Both groups will follow the same basic foot strengthening routine. Throughout the study, muscle strength, foot arch height, and dynamic balance will be measured before, during, and after the intervention. Researchers will monitor progress to determine the effectiveness of each exercise program in improving lower limb strength and functional balance in people with flexible flat feet.

This research aims to compare two rehabilitation exercises for male overhead athletes aged 17 to 35 with chronic rotator cuff tendinopathy, a condition causing pain and impaired shoulder function. The study evaluates whether rotator cuff drills or progressive resistance exercises better improve pain, stability, and functional performance. It addresses gaps in evidence for sport-specific rehab in overhead athletes and uses a randomized, single-blinded design to ensure unbiased results. Participants are randomly assigned to one of two groups Group A performs rotator cuff drills such as plyometric medicine ball throws and wall dribbles, while Group B completes progressive resistance exercises using resistance bands with increasing load. Both groups follow a 12-week program with three exercise sessions per week, each preceded by a standardized 20-minute warm-up, following the FIIT principle Frequency, Intensity, Time, Type. Throughout the study, participants undergo assessments at baseline, 6 weeks, and 12 weeks using tools like the Numeric Pain Rating Scale NPRS for pain, the Closed Kinetic Chain Upper Extremity Stability Test CKCUEST for stability, and the Upper Limb Rotation Test ULRT for function. Data are analyzed statistically to compare changes within and between groups. The study includes careful monitoring and aims to provide evidence-based recommendations for managing rotator cuff tendinopathy in overhead athletes.

This research aims to evaluate the combined effects of Sustained Natural Apophyseal Glides SNAGs and Cognitive Behavioral Therapy CBT on pain, posture, and disability in adults with non-specific neck pain. Non-specific neck pain is a common condition that causes discomfort, reduces the craniovertebral angle, and leads to functional disability. The study seeks to explore both physical and psychological treatment approaches to improve long-term outcomes and patient well-being. The trial is a randomized controlled study involving participants aged 18 to 28 years diagnosed with non-specific neck pain. Participants will be randomly assigned to one of two groups. Both groups will receive conventional therapy including a hot pack and myofascial release, followed by SNAGs therapy. Group A will then receive 20-minute CBT sessions focused on pain management and posture education using visual aids, twice weekly for four weeks. Group B will undertake 20 minutes of cervical stabilization exercises involving bracing techniques, isometric exercises, and functional training, also twice weekly for four weeks. Participants will be assessed for pain intensity, craniovertebral angle, and disability at the start and after the four-week intervention using standardized tools such as the Numeric Pain Rating Scale and Neck Disability Index. Data will be analyzed to compare the effects of the two treatments on these outcomes. The study is double-blinded and aims to provide insights on the combined physical and psychological benefits of the treatments. The total participation duration includes these four weeks of treatment and assessments.