Gujranwala

Breast abscess is a localized collection of pus that often develops after mastitis, especially in lactating women but also in prepubertal females. Its occurrence is higher in developing countries, reaching up to 16%. This condition usually causes painful, tender swelling of the breast and can result from factors like poor hygiene, milk stasis, and infections. Traditional treatment involves surgical incision and drainage with antibiotics, but this can cause scarring and require hospital stays. The study aims to compare systemic antibiotics against local antibiotic injections alongside ultrasound-guided needle aspiration to manage breast abscesses more effectively and reduce complications. The trial evaluates two approaches needle aspiration combined with systemic antibiotics and needle aspiration combined with local instillation of antibiotics. Needle aspiration is a minimally invasive procedure guided by ultrasound, avoiding hospital stays and general anesthesia. Local antibiotic instillation is being studied as an addition to aspiration to potentially reduce the number of procedures needed and lower failure rates compared to systemic antibiotics alone. The study involves random assignment to one of these treatment groups. Participants will be monitored from enrollment until nine days after treatment starts. Researchers will assess clinical symptoms like skin redness, pain, tenderness, and ultrasound evidence of pus to determine treatment effectiveness. The study also tracks whether local antibiotics reduce the need for repeated aspirations and complications. Safety and treatment success will be carefully observed during this period to better understand the benefits of local antibiotic use in breast abscess management.

Researchers are evaluating whether adding platelet-rich plasma PRP to fractional carbon dioxide CO2 laser treatment improves the appearance of moderate-to-severe acne scars compared with laser treatment alone. This randomized controlled trial will involve 70 adults aged 18 to 40 years with moderate-to-severe facial acne scars. The study aims to see if PRP enhances the effectiveness and safety of laser therapy while improving patient satisfaction. Participants will be randomly assigned to one of two groups. One group will receive fractional CO2 laser therapy combined with topical PRP applied immediately after treatment. The other group will receive fractional CO2 laser therapy alone, with a placebo procedure to maintain blinding. Both groups will undergo three treatment sessions spaced four weeks apart. PRP is prepared using a standardized double-spin centrifugation method from the participants own blood. During the study, participants will be assessed at baseline and each visit for acne scar severity using the Goodman and Baron Quantitative Acne Scar Scale, along with redness, swelling, pain, and patient satisfaction. Standardized photographs will support evaluations. Data will be analyzed with statistical tests, keeping patient groups blinded. Safety and treatment effects will be closely monitored across the 12-week follow-up period.