San Javier

Researchers are evaluating whether ultrasound-guided alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas. This study compares sclerotherapy to expectant management to determine which approach better helps manage symptoms and quality of life impacts associated with this common form of endometriosis. Participants are randomly assigned to either receive ultrasound-guided alcohol sclerotherapy involving puncture and alcohol treatment of the cysts or to be managed expectantly with standard pain management if needed. The sclerotherapy procedure involves a 15-minute application of absolute ethanol followed by a wash. Both groups will be followed for six months, with assessments at baseline and 6 months post-treatment. During the study, participants will complete quality of life and pain assessments using standardized tools, provide blood and urine samples for biomarker analysis, and undergo ovarian reserve evaluations. Researchers will monitor adverse events, cyst recurrence, fertility outcomes, and healthcare costs. Pregnancy outcomes will be followed for an average of two years. The main outcome is quality of life measured at baseline and 6 months.

Researchers are investigating whether higher blood lactate levels in people with metabolic syndrome contribute to their reduced fat breakdown and glucose tolerance. The study compares metabolically healthy individuals to those with metabolic syndrome, focusing on how elevated lactate affects carbohydrate and fat metabolism at rest, during exercise, and after an oral glucose load. This research uses advanced metabolic assessments to better understand lactates role beyond being a simple by-product. The study involves two groups metabolically healthy participants who receive either an intravenous sodium lactate infusion to raise blood lactate to levels seen in metabolic syndrome or a saline infusion as a control, and metabolic syndrome participants who receive only the saline infusion. Each trial includes a 150-minute resting period, an exercise session, and a 2-hour oral glucose tolerance test. Researchers measure insulin sensitivity, fat and carbohydrate oxidation, and use stable isotopes to track metabolism. Participants undergo blood sampling to assess hormones, metabolites, and cytokines. The study measures lipolysis rate and glucose tolerance changes when blood lactate is elevated, along with secondary outcomes like insulin sensitivity and various metabolic markers. The trial lasts for an average of two years, during which detailed metabolic data are collected to understand how lactate influences metabolic processes in different states.