San Javier

Researchers are evaluating whether ultrasound-guided alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas. This condition involves abnormal growth of endometrial tissue outside the uterus and can cause chronic pelvic pain and infertility. The study compares sclerotherapy to expectant management to see which approach better improves pain and quality of life using the EHP-5 score. Participants will be randomly assigned to either the sclerotherapy group, which undergoes ultrasound-guided puncture and alcohol injection, or the control group, which receives expectant management without intervention. The study focuses on evaluating pain relief, quality of life, pregnancy rates, recurrence, adverse events, and treatment costs over six months. During the study, participants will complete pain and quality of life assessments at the start and after six months. They will also provide blood and urine samples for biomarker analysis and have ovarian reserve tests. Researchers will monitor safety, recurrence of endometriomas, fertility outcomes, and cost-effectiveness. The goal is to understand the benefits and risks of sclerotherapy compared to no treatment over this time period.

Researchers are studying whether high blood lactate levels in people with metabolic syndrome cause their lower fat breakdown and poorer glucose tolerance. This study compares healthy individuals and those with metabolic syndrome, examining how lactate affects fat and carbohydrate metabolism at rest, during exercise, and after a glucose drink. The research uses advanced metabolic assessments to explore lactate's role as a signaling molecule, not just a by-product of metabolism. The study involves 10 healthy and 10 metabolically impaired participants matched by sex and activity. Healthy participants undergo two sessions: one receiving intravenous sodium lactate to raise blood lactate to levels seen in metabolic syndrome, and the other receiving a saline infusion as a control. The metabolically impaired group receives only the saline infusion. Each session includes a 150-minute resting period, an exercise phase, and a 2-hour oral glucose tolerance test. During the sessions, researchers measure insulin sensitivity, fat and carbohydrate use via indirect calorimetry, and glucose and glycerol turnover using stable isotopes. Blood samples are collected to analyze hormones, metabolites, and cytokines. The primary outcomes focus on lipolysis rates and glucose tolerance under elevated lactate conditions, with the study lasting about two years for each participant.