Sant Boi De Llobregat

Researchers are collecting detailed information about patients with venous thromboembolism (VTE), which includes blood clots in veins such as deep-vein thrombosis and pulmonary embolism. The project aims to improve doctors' understanding of VTE, especially in patients often excluded from clinical trials, like pregnant women, elderly individuals, cancer patients, and those with other complex health issues. The goal is to reduce deaths, clot recurrence, bleeding problems, and artery-related events by sharing this knowledge widely. The study involves gathering extensive data on each patient's health status, treatments, and outcomes during the first three months of therapy. This registry is available online to help doctors quickly find information on patients with similar medical profiles and make informed decisions about managing high-risk individuals. There are no specific interventions being tested; instead, the focus is on collecting real-world patient data. Participants provide informed consent and are followed for at least three years to monitor for new clot events and complications. Researchers track recurrences of VTE, bleeding episodes, and deaths, aiming to create tools that predict which patients are most at risk for problems. This ongoing data collection supports improving care and guiding treatment decisions for diverse patient groups over time.

Researchers are evaluating whether ultrasound-guided alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas. This condition involves abnormal growth of endometrial tissue outside the uterus and can cause chronic pelvic pain and infertility. The study compares sclerotherapy to expectant management to see which approach better improves pain and quality of life using the EHP-5 score. Participants will be randomly assigned to either the sclerotherapy group, which undergoes ultrasound-guided puncture and alcohol injection, or the control group, which receives expectant management without intervention. The study focuses on evaluating pain relief, quality of life, pregnancy rates, recurrence, adverse events, and treatment costs over six months. During the study, participants will complete pain and quality of life assessments at the start and after six months. They will also provide blood and urine samples for biomarker analysis and have ovarian reserve tests. Researchers will monitor safety, recurrence of endometriomas, fertility outcomes, and cost-effectiveness. The goal is to understand the benefits and risks of sclerotherapy compared to no treatment over this time period.

Researchers are evaluating whether the PIPPEP digital platform can improve treatment adherence and outcomes in young adults aged 18 to 40 who are receiving early intervention for psychosis. The study aims to compare the use of this digital tool alongside usual care to usual care alone. The trial also investigates the platform's cost-effectiveness, its dissemination, and the impact on clinical and functional outcomes such as symptom severity, medication side effects, self-stigma, risk, comorbid symptoms, and social functioning. Participants are randomly assigned to either an experimental group that receives access to the PIPPEP platform in addition to standard treatment or a control group that receives standard treatment alone. The PIPPEP platform provides psychoeducational content, regular self-assessment questionnaires, bidirectional messaging with the clinical team, a reward system with gamification, and a personal document folder. The intervention lasts up to five years, with personalized support offered to platform users during follow-up visits. During the study, participants complete questionnaires at the start, six months, and twelve months, with weekly assessments of anxiety and depression. The questionnaires help monitor symptoms, emotional state, side effects, and treatment adherence, and results are securely stored in their medical records. Researchers will assess adherence to psychosocial treatment over time and evaluate various clinical and functional outcomes. The study takes place at a single center and involves ongoing monitoring through the platform and regular clinical assessments.

Researchers are evaluating how combining water aerobics and Metacognitive Training (MCT) affects people with psychosis. The study aims to see if doing both together improves clinical symptoms, cognition, metacognition, psychosocial aspects, motor coordination, and physical health more than each intervention alone. They also want to explore how the levels of SP1 and SP4 biomarkers change based on the treatment received. The hypothesis is that the combined approach may provide greater benefits in symptoms and cognitive and social functions. Participants are divided into three groups: one doing water aerobics, one doing MCT, and one doing both interventions together. Water aerobics sessions last one hour per week for three months, focusing on motor coordination, strength, and cardiovascular fitness led by a specialist trainer. MCT sessions also last one hour weekly for three months and are conducted by a trained psychologist who addresses common cognitive biases in psychosis, with each session targeting topics like emotion recognition or memory. Those in the combined group attend both weekly sessions. Throughout the study, participants will be assessed at the start and after three months on various measures including cognitive insight, cognitive bias, stress response, and molecular biomarkers. Researchers will monitor changes in these areas to understand the interventions' effects. The total participation lasts three months, during which clinical, cognitive, psychological, and physical evaluations will be carried out to measure treatment impact and safety.

This research aims to develop and test an eHealth platform called ePro-Schools to promote physical activity, healthy eating, and reduce sedentary behavior among adolescents from socially disadvantaged backgrounds in Central Catalonia. The project responds to the lack of targeted public health and educational policies for this group by co-designing the platform with input from adolescents, teachers, school staff, and policymakers. The study focuses on students attending 1st to 3rd year of secondary school (ages approximately 11 to 16) and includes about 1000 adolescents from six schools. The intervention includes two digital platforms: an interactive Intervention Platform for students and physical education teachers, and an Information Platform with educational resources for students, teachers, and families. Adolescents will access over 15 modules on physical activity and nutrition, while teachers receive 8 pedagogical modules designed to enhance lessons and encourage student participation. Schools are randomized 1:1 to either the intervention group using the ePro-Schools platform or a control group with access only to the information platform. Participants will be assessed at baseline, at the end of the school year (post-intervention), and at a nine-month follow-up. Evaluations include physical activity levels and intensities, sedentary behavior, and dietary habits as primary outcomes. Secondary outcomes include fitness, water consumption, quality of life, depressive symptoms, social isolation, and sleep quality. The study also includes cost-effectiveness and process evaluations, using questionnaires, interviews, and focus groups to measure adoption, acceptability, and feasibility. Families and school staff will also participate in the project to support its implementation and scaling.