Gallivare

Researchers are studying patients with abdominal rectus diastasis who are eligible for surgical correction to evaluate the effects of a postoperative rehabilitation program. The trial aims to determine if structured abdominal exercises after surgery improve abdominal wall function at three and twelve months. Additionally, the study examines whether connective tissue components differ in patients with abdominal rectus diastasis compared to healthy individuals. All participants undergo surgery involving plication of the linea alba. Blood samples are taken before surgery and on the first postoperative day. During surgery, biopsies of the skin, connective tissue, and rectus muscle are collected. After surgery, participants are randomly assigned to receive a postoperative rehabilitation program designed by a physical therapist. Follow-up assessments occur at three and twelve months after surgery. These include physical tests such as the time to complete five sit-to-stand repetitions and the number of deadlift repetitions with 20 kilograms. The study monitors abdominal wall function and connective tissue characteristics to understand the treatment effects and recovery.

Researchers are evaluating whether using the World Health Organization's Labour Care Guide (LCG) instead of standard care for monitoring labor progress can improve outcomes for newborns and mothers. This study compares these two guidelines to see if the LCG can reduce adverse neonatal outcomes, such as perinatal mortality, neonatal complications, and the need for cesarean sections during labor. The research also looks at other perinatal interventions, complications, and economic factors, using a multicenter, stepped-wedge cluster randomized trial design conducted from 2023 to 2025 in Sweden. Participants will receive care based on either the WHO's LCG or standard labor monitoring guidelines. The LCG is a next-generation partograph designed to follow the latest intrapartum care recommendations. The study involves multiple delivery units where women in active labor receive monitoring according to the assigned guideline. Researchers will compare outcomes such as neonatal morbidity, cesarean section rates, use of oxytocin, postpartum hemorrhage, labor duration, and experiences of women, their partners, and healthcare providers. Throughout the study, participants will be monitored for neonatal complications including low Apgar scores, hypoxic ischemic encephalopathy, intracranial hemorrhage, seizures, meconium aspiration syndrome, and neonatal unit admissions. The study will also assess maternal outcomes and collect feedback via questionnaires and interviews about childbirth experiences and guideline compliance. The primary outcomes are adverse neonatal events and intrapartum cesarean rates, with follow-up from 12 weeks up to 18 months after birth to gather comprehensive data on health and safety.

Researchers are conducting a multicenter, single-blinded, randomized controlled trial to study patients with ventral hernias that have an aperture width between four and eight centimeters. The study aims to compare the effects of a multimodal preoptimization program with surgery alone, focusing on the rate of complications three months after surgery. During the surgical procedure, biopsies of skin, muscle, and fascia will be collected, along with blood samples taken before and after surgery, to examine the molecular impact of preoptimization on collagen metabolism.

Researchers are evaluating whether remote video exercise-based cardiac rehabilitation (exCR) can increase participation in rehabilitation sessions after a myocardial infarction (heart attack), compared to traditional center-based exCR. The study is designed as a national multicenter registry-based cluster randomized crossover clinical trial, preceded by a feasibility and safety study conducted during the COVID-19 pandemic. Patients diagnosed with type 1 myocardial infarction and aged 18 to 79 years are included, with long-term follow-up planned at 1 and 3 years after the cardiac event. The study involves two phases: first, a feasibility study offering remote exCR at participating sites until the pandemic peak subsides, ending in August 2022; second, a randomized trial where cardiac rehabilitation centers are assigned to provide either remote exCR, usual center-based exCR, or a combination based on patient preference at intervention sites, while control sites offer only center-based exCR. The exercise program is standardized, requiring at least 24 supervised sessions over 3 to 4 months, each session including aerobic exercise and strength training at specified intensity levels. Success is defined as attending at least 75% of sessions within four months. Participants will be monitored through their attendance and adherence to the exercise sessions. Researchers will assess the average number of exCR sessions completed over 3 to 4 months. Additional evaluations include safety monitoring and long-term follow-up at 1 and 3 years to observe outcomes after the initial cardiac event. The study also considers patient access to internet for remote participation and evaluates exercise test results to ensure safety during rehabilitation.