Gustavsberg

Researchers are investigating whether online transdiagnostic cognitive behavior therapy CBT can effectively reduce symptoms in adults with common mental disorders such as anxiety, depression, and stress-related disorders within primary care. This randomized controlled trial compares online transdiagnostic CBT with the usual care provided in primary care settings to see if psychiatric symptoms improve more with the online therapy. The study also aims to explore effects on quality of life, work ability, and neuroticism, as well as cost-effectiveness and sickness absence. Participants are randomly assigned to either online transdiagnostic CBT or primary care as usual. The online CBT is delivered through a secure web platform featuring psychoeducation, worksheets, and exercises arranged in modules with weekly written feedback from a therapist. Some face-to-face or video sessions may be included for support. The usual care group receives standard health services from primary care providers without intervention control by the research team. During the study, participants complete assessments at baseline, weeks 2, 4, 6, 8, 10, and follow-ups at 1 and 2 years. Researchers measure changes in symptoms using the Depression Anxiety Stress Scales-21 DASS-21 and evaluate quality of life, functional impairment, work ability, and sickness absence. Participants provide informed consent, complete baseline assessments, and are monitored through questionnaires and interviews throughout the study, which is planned to continue until 2029.

Researchers are evaluating the effectiveness of online transdiagnostic cognitive behavior therapy CBT compared to usual primary care for adults with subsyndromal mental ill-health. This trial focuses on individuals who experience mental health symptoms like anxiety, depression, or stress that do not meet criteria for specific psychiatric disorders but still require treatment. The study aims to see if online CBT can provide better symptom improvement, quality of life, and functional outcomes while also assessing cost-effectiveness and treatment moderators. Participants will be randomly assigned to either online transdiagnostic CBT or care as usual. The online CBT is delivered through a secure web platform offering psychoeducation, worksheets, and exercises in modules, with weekly written feedback from a therapist primarily via messaging. Some face-to-face or video sessions may be provided for technical or therapeutic support. Those in the care-as-usual group will receive standard primary care treatments, which are not controlled by the study but are expected to be active treatments. During the study, participants will complete assessments at baseline, during treatment, and at 10 weeks, as well as 1- and 2-year follow-ups. Measurements include symptom changes using the Depression Anxiety Stress Scales-21, quality of life, work ability, functional impairment, sickness absence, and neuroticism. The total study duration includes these follow-ups, and data will be analyzed to compare symptom improvement and other outcomes between the two groups. The trial plans to enroll 500 adults and is sponsored by Karolinska Institutet.