Gustavsberg

Researchers are evaluating the effectiveness of online transdiagnostic cognitive behavioral therapy (CBT) compared to usual primary care for adults with common mental disorders such as anxiety, depression, and stress-related conditions. The study aims to determine if this internet-based CBT can provide better symptom improvement and also assess its impact on quality of life, functional ability, neuroticism, and cost-effectiveness. This randomized controlled trial involves 500 adult primary care patients recruited mainly from centers in Stockholm, Sweden. Participants will be randomly assigned to either receive online transdiagnostic CBT or continue with care as usual in primary care. The CBT is delivered through a secure web platform with modules containing psychoeducation, worksheets, exercises, and weekly written feedback from a therapist via messages. Some face-to-face or video sessions for technical and therapeutic support are allowed. The usual care group will receive standard primary care treatment provided by qualified healthcare professionals without research control over the interventions. During the study, participants will be assessed using the Depression Anxiety Stress Scales-21 (DASS-21) at multiple time points: baseline, weeks 2, 4, 6, 8, 10 (primary endpoint), and at 1- and 2-year follow-ups. These evaluations will help measure symptom changes over time. Participants must complete baseline assessments and provide informed consent. The study monitors progress, safety, and long-term outcomes for up to 2 years after treatment starts.

Researchers are evaluating the effectiveness of online transdiagnostic cognitive behavior therapy (CBT) compared to usual primary care in treating adults with subsyndromal mental ill-health, which includes symptoms of anxiety, depression, or stress that do not meet criteria for a specific psychiatric disorder. This randomized controlled trial aims to determine if online CBT provides better symptom improvement than standard care in a primary care setting. The study also seeks to explore the effects on quality of life, functional impairment, neuroticism, treatment outcome moderators and mediators, as well as cost-effectiveness, including sickness absence. Participants will be randomly assigned to receive either online transdiagnostic CBT or primary care as usual. The online CBT involves a secure web platform delivering psychoeducation, worksheets, and exercises in modules, with weekly written feedback from a therapist who gradually grants access to treatment content. Most therapist-patient interactions occur via messaging on the platform, but one to three face-to-face or video sessions are allowed for technical or therapeutic support. The usual care group will receive standard primary care treatments, which are not controlled by the study but are expected to be active interventions. During the study, participants will be assessed at baseline, weeks 2, 4, 6, 8, and 10, as well as at 1- and 2-year follow-ups. The main outcome is the change in symptoms measured by the Depression Anxiety Stress Scales-21 (DASS-21). Researchers will monitor symptom changes over time using statistical methods accounting for individual differences. The total participation includes initial treatment and long-term follow-up assessments to evaluate both short- and long-term effects of the interventions.