Lycksele

Researchers are evaluating treatments for elderly patients aged 75 and older who have an undisplaced femoral neck fracture (uFNF), classified as Garden I-II. The study compares whether replacing the hip (arthroplasty) reduces the need for further surgeries compared to preserving the hip with internal fixation. The goal is to lower the combined risk of needing reoperation or death within 1 to 2 years after surgery. Participants are randomly assigned to one of two treatment groups using the Swedish Fracture Register. One group receives arthroplasty, which may be either a hemi or total hip replacement depending on hospital routine based on patient age and mobility. The other group undergoes internal fixation, where the fracture is repaired using 2-3 screws, pins, or a sliding hip screw device, again according to hospital routine. Both treatments are devices applied to stabilize or replace the hip after fracture. During the study, participants are monitored for outcomes including the rate of additional surgeries and mortality up to 2 years after their initial operation. The main measure combines these two outcomes into a single variable to evaluate overall treatment success. The entire process is registered and randomized within the Swedish Fracture Register system, ensuring consistent follow-up and data collection.

This research aims to explore complications following the closure of a temporary loop ileostomy in patients who have undergone rectal cancer surgery. The study focuses on two main questions: whether the choice of anastomotic method affects the postoperative recovery, and whether using a prophylactic mesh during stoma site closure reduces the occurrence of hernias. The study is a prospective randomized multicenter trial involving patients with rectal neoplasm. Participants will be randomly assigned to receive either a stapled or hand-sewn anastomosis after ileostomy closure. Additionally, they may be randomized to have the stoma site closed using either a lightweight mesh placed under the muscle (retromuscular) or a long-lasting suture. The anterior fascia and skin are closed with running monofilament sutures, with the skin closure performed using a pursestring technique. During the study, researchers will monitor participants for postoperative complications including small bowel obstruction within 30 days and stoma site hernia formation over two years. The assessments will gather data on healing and complications to evaluate the impact of the different surgical techniques. Participant involvement includes follow-up for safety and effectiveness outcomes over the specified periods.

Researchers are conducting a multicenter, single-blinded, randomized controlled trial to study patients with ventral hernias that have an aperture width between four and eight centimeters. The study aims to compare the effects of a multimodal preoptimization program with surgery alone, focusing on the rate of complications three months after surgery. During the surgical procedure, biopsies of skin, muscle, and fascia will be collected, along with blood samples taken before and after surgery, to examine the molecular impact of preoptimization on collagen metabolism.