Mora

Researchers are evaluating the effects of a postoperative rehabilitation program for patients undergoing surgical correction of abdominal rectus diastasis, a condition where the abdominal muscles separate. The study aims to determine if structured abdominal exercises after surgery improve abdominal wall function at three and twelve months and to compare connective tissue components in patients with this condition to healthy individuals. This randomized controlled trial is conducted in Sweden and sponsored by Ume University. Participants will all undergo surgery to correct the abdominal rectus diastasis by plication of the linea alba. They are randomly assigned to one of two groups one group follows a postoperative rehabilitation program designed by a physical therapist, while the other group is allowed to exercise freely without a structured program. Blood samples and tissue biopsies from skin, connective tissue, and rectus muscle are collected before and during surgery. Follow-up assessments occur at three and twelve months after surgery. During the study, participants will be evaluated using physical function tests such as the 5 times sit to stand test and repetitions of a 20-kilogram deadlift at three and twelve months post-surgery. They will also complete questionnaires assessing pain, disability, and pelvic floor distress. Safety and progress are monitored through clinical visits and sample collections. The total participation time covers pre-surgery, surgery day procedures, and follow-ups at three and twelve months.

This research aims to determine if hip replacement surgery arthroplasty can reduce the need for additional operations compared to internal fixation in elderly patients with an undisplaced femoral neck fracture. Patients aged 75 years and older with this type of fracture will be included and randomly assigned to one of two treatments through the Swedish Fracture Register platform. The study focuses on combining reoperation rates and mortality into a single main outcome measure to evaluate which treatment offers better results. Participants will receive either arthroplasty, which may be hemi or total hip replacement depending on the patients condition and surgeons decision, or internal fixation using screws, pins, or a sliding hip screw device based on hospital routine. The study is a randomized controlled trial without blinding, comparing these two device-based treatments for hip fractures in elderly patients. During the study, researchers will monitor the combined rate of reoperations and mortality for 1 to 2 years after surgery. Additional outcomes include reoperation rates, short- and long-term mortality, and patient-reported physical function one year after surgery. Participants will be followed up to assess these outcomes, with care taken to track their progress and safety over the study period.

Researchers are evaluating the effectiveness and safety of apixaban as a stroke prevention treatment in adults with stage 5 chronic kidney disease CKD who also have atrial fibrillation AF or atrial flutter AFL. This study compares apixaban to no anticoagulation to see if it reduces the risk of ischemic stroke without increasing fatal or brain bleeding events. The trial also examines all-cause mortality, cardiovascular events, and major bleeding risks in this patient group. Participants are randomly assigned to one of two groups one receiving apixaban 2.5 mg twice daily plus standard care, and the other receiving standard care without anticoagulation. The study is open-label and conducted over 12 to 72 months across around 50 sites in several European countries. Patients already on warfarin, apixaban, or low molecular weight heparin may join after stopping their current anticoagulation. Routine blood tests are done at inclusion. During the trial, participants will be monitored for ischemic stroke, intracranial or fatal bleeding, death, cardiovascular events, and major bleeding according to established criteria. Additional outcomes include thromboembolic events and kidney transplant-related complications. The study lasts up to 72 months per participant or until a set number of events occur. Safety and efficacy data are reviewed by independent boards throughout the study.

This clinical trial investigates the use of Negative Pressure Wound Therapy NPWT in adults undergoing emergency laparotomy surgeries. The main aim is to determine if NPWT can reduce wound complications such as surgical site infections, wound dehiscence, and seromas compared to regular dressings. The study involves randomizing patients to either NPWT or standard dressings at the time of skin closure, with no other changes to their care. Participants will receive either the Avance Solo NPWT system, which uses suction to clear fluids from the wound for 7 days after surgery, or standard postoperative dressings like Mepilex Border Post-Op. The treatment period lasts for 7 days, and patients are followed up at 14, 30 days, and 1 year. Follow-up includes visits, surveys, and an optional CT scan to assess incisional hernia formation. Throughout the study, participants will undergo assessments including wound complication monitoring at 14 and 30 days, quality of life and scar satisfaction surveys, and evaluation of infections, reoperations, and healthcare use. Some secondary outcomes track long-term events like hernias or bowel obstructions up to 5 years. The total study duration extends to 10 years, ensuring thorough long-term safety and effectiveness monitoring.

Researchers are evaluating a Scandinavian decision support tool designed to help manage children with mild and moderate head injuries who seek care in emergency departments. The study focuses on whether these guidelines can reliably identify children with important complications, such as bleeding in or around the brain, following head trauma. This is a prospective, multicenter observational study including hospitals in Sweden and Norway that routinely treat children with traumatic brain injuries. The study involves no changes to usual care all children receive standard management regardless of participation. Data is collected on patient history, symptoms, and treatment during the emergency visit and entered into electronic case report forms. Follow-up is conducted through medical records and electronic questionnaires sent to guardians at 1, 3, and 4 months after injury, with long-term outcomes assessed beyond 6 months. A sub-study will also explore blood and saliva biomarkers to predict brain injury in certain cases. Participants will be monitored through clinical examinations, CT scan results, and questionnaires about recovery. The study measures outcomes like clinically important brain injury within one week, need for neurosurgery, CT findings, hospital admission, and time to full recovery. Safety and long-term effects are followed for up to four years. Data is analyzed to assess how well the Scandinavian and other international guidelines predict outcomes for children with head trauma.