Mora

Researchers are studying patients with abdominal rectus diastasis who are eligible for surgical correction to evaluate the effects of a postoperative rehabilitation program. The trial aims to determine if structured abdominal exercises after surgery improve abdominal wall function at three and twelve months. Additionally, the study examines whether connective tissue components differ in patients with abdominal rectus diastasis compared to healthy individuals. All participants undergo surgery involving plication of the linea alba. Blood samples are taken before surgery and on the first postoperative day. During surgery, biopsies of the skin, connective tissue, and rectus muscle are collected. After surgery, participants are randomly assigned to receive a postoperative rehabilitation program designed by a physical therapist. Follow-up assessments occur at three and twelve months after surgery. These include physical tests such as the time to complete five sit-to-stand repetitions and the number of deadlift repetitions with 20 kilograms. The study monitors abdominal wall function and connective tissue characteristics to understand the treatment effects and recovery.

Researchers are evaluating treatments for elderly patients aged 75 and older who have an undisplaced femoral neck fracture (uFNF), classified as Garden I-II. The study compares whether replacing the hip (arthroplasty) reduces the need for further surgeries compared to preserving the hip with internal fixation. The goal is to lower the combined risk of needing reoperation or death within 1 to 2 years after surgery. Participants are randomly assigned to one of two treatment groups using the Swedish Fracture Register. One group receives arthroplasty, which may be either a hemi or total hip replacement depending on hospital routine based on patient age and mobility. The other group undergoes internal fixation, where the fracture is repaired using 2-3 screws, pins, or a sliding hip screw device, again according to hospital routine. Both treatments are devices applied to stabilize or replace the hip after fracture. During the study, participants are monitored for outcomes including the rate of additional surgeries and mortality up to 2 years after their initial operation. The main measure combines these two outcomes into a single variable to evaluate overall treatment success. The entire process is registered and randomized within the Swedish Fracture Register system, ensuring consistent follow-up and data collection.

Researchers are evaluating the safety and effectiveness of apixaban to prevent strokes in adults with stage 5 chronic kidney disease (CKD) who also have atrial fibrillation (AF), a heart rhythm disorder. This phase 3b clinical trial compares apixaban treatment to no anticoagulation to see if apixaban lowers the risk of ischemic stroke without causing unacceptable increases in fatal or brain bleeding. The study also looks at the risk of death from any cause, cardiovascular events, and major bleeding in this patient group. Participants are randomly assigned to receive either apixaban 2.5 mg tablets twice daily along with standard care or standard care without anticoagulation. The study is open-label, meaning both patients and doctors know the treatment given. Apixaban will be prescribed and renewed by the local investigator. The study lasts between 12 and 72 months and includes about 1000 to 1400 patients from multiple sites in Sweden, Finland, Norway, Iceland, Poland, and possibly other European countries. During the study, participants will have routine blood tests including kidney function and coagulation checks. Researchers will monitor the time to first ischemic stroke, fatal or intracranial bleeding, overall mortality, cardiovascular events, and major bleeding events. A safety board will oversee the trial, and outcomes will be reviewed independently. The study may also explore outcomes related to kidney transplant complications and thrombosis. Participation ends after 72 months or when enough primary events have occurred.

Researchers are investigating Negative Pressure Wound Therapy (NPWT) in adults undergoing emergency laparotomy to see if it reduces wound complications such as surgical site infection, wound dehiscence, and seroma. This study compares NPWT to standard postoperative dressings to find out if NPWT is more effective at decreasing these complications. The study also looks at secondary outcomes like length of hospital stay, peri-wound blistering, and patient satisfaction. Participants will be randomly assigned at the time of skin closure to receive either the Avance Solo Negative Pressure Wound Therapy System or a standard surgical dressing called Mepilex Border Post-Op. The NPWT system includes a portable, battery-powered pump and dressing that applies suction to the wound. The standard dressing is a self-adhesive absorbent surgical dressing designed for acute wounds. No other care aspects will be changed during the study. Participants will be followed up at 7, 30, and 365 days after surgery with visits and surveys. They will also be offered a CT scan to assess for incisional hernia formation. Researchers will monitor wound complications and other outcomes over this time. The total participation time covers one year after the surgery to evaluate both short- and long-term results and safety.

Researchers are evaluating the Scandinavian guidelines designed to manage children with mild and moderate head injuries who visit emergency departments in Sweden and Norway. The study aims to determine how sensitive these guidelines are in identifying important patient outcomes, such as serious brain injuries, without introducing any new treatments. This observational study includes children under 18 years old who have suffered blunt head trauma within 24 hours and seeks to improve the accuracy of decision-making tools used in emergency care. Participants will be managed according to their hospital's usual care practices without any changes or experimental treatments. Doctors and nurses will collect detailed information about each child's injury, symptoms, and treatment in a web-based case report form. In some centers, a sub-study will collect blood and saliva samples within 12 hours of injury to analyze biomarkers that might predict brain injury. CT scans, when performed, will be reviewed by certified radiologists. During the study, follow-up information will be gathered from medical records and questionnaires sent to guardians at 1, 3, and 4 months after the injury, with additional long-term follow-up after 6 months. Researchers will track outcomes like the number of children with serious brain injuries within one week of trauma. Data will be analyzed statistically to assess how well the guidelines predict important outcomes and to explore the potential of biomarkers to reduce unnecessary CT scans. The study plans to enroll up to 5,300 children over about four years.