Trelleborg

Researchers are evaluating postoperative pain management in patients undergoing total knee arthroplasty (TKA) due to osteoarthritis of the knee. This Phase 4 randomized clinical trial compares local infiltration analgesia (LIA) alone to a combination of LIA with ultrasound-guided nerve blocks targeting the saphenous nerve (SN), nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN). The study aims to determine if this combination improves pain control, reduces opioid use, and preserves motor function necessary for early mobilization after surgery. Participants are randomly assigned to either receive LIA alone or LIA combined with the three sensory nerve blocks under ultrasound guidance. The nerve blocks involve injections of ropivacaine with clonidine at specific nerve sites, while LIA is administered by the surgeon before wound closure around the knee. All patients receive standard preoperative multimodal analgesia including etoricoxib, paracetamol, oxycodone, and betamethasone. Anesthesia type (general or spinal) is chosen based on clinical need and is independent of group assignment. During the study, pain intensity is measured using the Numerical Rating Scale (NRS) at several time points after surgery, including 1 hour, 4 hours, 24 hours, and 14 days postoperatively. Researchers also monitor opioid consumption, time to mobilization, postoperative nausea and vomiting, neurological complications, and length of hospital stay. Participants are followed throughout their hospital stay, and randomization and treatment details are carefully documented and verified to assess the effectiveness and safety of the interventions.

This research aims to understand how different daylight-like lighting conditions at work affect radiographers' alertness, energy, well-being, and sleep quality. The study will determine if enhanced light environments improve these factors compared to no enhancement and find the best lighting setup for radiology staff. It uses a quasi-experimental crossover design where each participant experiences multiple lighting conditions to identify the most effective light recipe. Participants will work at radiology department workstations equipped with floor lamps that can be set to various light recipes mimicking natural daylight changes. The study involves switching between enhanced light and non-enhanced light every two weeks across four different light recipes. This cycling allows comparison of effects on staff energy, activity, and sleep quality during darker months at Skåne University Hospital. During the study, participants will complete surveys about their alertness, well-being, and sleep disturbances using tools like the Karolinska Sleepiness Scale, WHO-5 Well-Being Index, and PROMIS Sleep Disturbance questionnaire. They will wear activity monitors after work to track sleep objectively and provide saliva samples to measure cortisol and melatonin. Data collection spans 16 to 20 weeks, with assessments occurring multiple times weekly to capture changes across seasons and light conditions.