Trelleborg

Researchers are evaluating pain management techniques in people undergoing total knee replacement surgery due to osteoarthritis. The study compares local infiltration analgesia LIA alone with a combination of LIA plus three sensory nerve blocks the saphenous nerve SN block, nerve to vastus medialis NVM block, and anterior femoral cutaneous nerve AFCN block. This randomized clinical trial aims to find out if adding these nerve blocks improves pain control, reduces opioid use, and helps early mobilization without affecting muscle function. Participants are randomly assigned to one of two groups. One group receives ultrasound-guided nerve blocks to the NVM, SN, and AFCN nerves before surgery along with LIA administered by the surgeon during the operation. The other group receives only the LIA during surgery without nerve blocks. The nerve blocks involve specific doses of ropivacaine with clonidine injected near the nerves under ultrasound guidance, while the LIA involves ropivacaine with adrenaline injected around the knee joint and surrounding tissues. Both groups receive standard pain medications before surgery. During the study, participants will be assessed for pain intensity using a numerical rating scale at several time points up to 14 days after surgery. Researchers will also track opioid use, time to start moving after surgery, nausea and vomiting, neurological side effects, and hospital stay length. Neurological complications will be followed for up to six months if they occur. Anesthesia type, either general or spinal, is chosen based on clinical need and independently of group assignment. The study will last from preoperative randomization until follow-up assessments after surgery.

Researchers are evaluating the effects of the allergen-specific vaccine Alutard SQ Dog in adults aged 18 to 50 who have moderate-to-severe dog allergy. This phase 4, single-center study involves 40 men and women who will serve as their own controls. The study aims to assess how the vaccine impacts allergic symptoms and lung and nasal function after exposure to dog allergens. Participants will begin with baseline assessments including recording allergic symptoms, lung function tests using Peak Expiratory Flow PEF, nasal airflow using Peak Nasal Inspiratory Flow PNIF, and blood tests to measure allergen-specific IgE levels. They will then be exposed to dogs in a controlled environment and undergo the same assessments. Following this, they will start allergen immunotherapy with Alutard SQ Dog, following a 13-week up-titration to a maximum dose given every 6-8 weeks for up to three years, with the main treatment period lasting one year in this study. Throughout the study, participants will be monitored for changes in nasal symptoms, lung and nasal airflow, and laboratory parameters before and after allergen exposure at baseline and after one year of treatment. Symptom severity will be tracked using a Visual Analogue Scale VAS. Blood samples will be taken before and after the treatment period to measure changes in allergen-specific IgE. The total study duration is one year, with assessments occurring at the start and end of this period.

Researchers are investigating whether different lighting conditions can improve alertness, energy, well-being, and sleep quality among radiographers working in a radiology department. The study aims to identify the best light setting, or light recipe, that benefits staff the most by comparing standard lighting to enhanced lighting environments. This research uses a quasi-experimental crossover design, allowing each participant to experience both lighting conditions for accurate comparison. Participants will work in either an enhanced light environment, where a floor lamp mimics natural daylight, or a non-enhanced light environment with the lamp turned off. These conditions will each last two weeks before switching, and this cycle will repeat across four different light recipes. The study will take place during darker months and involve 18 radiology staff members at up to 20 workstations. Throughout the study, participants will complete surveys about their sleep, energy, and well-being, including the Karolinska Sleepiness Scale, PROMIS Sleep Disturbance, and WHO-5 Well-Being Index. They will also wear activity bands to track sleep objectively outside work hours and provide saliva samples to measure cortisol and melatonin levels. Measurements will be taken regularly over 16 to 20 weeks, depending on the inclusion timing. This detailed monitoring helps assess how lighting affects staff health and performance.