Vanersborg

Researchers are conducting a large observational safety study called EXCEED to assess the risk of developing pancreatic cancer in adults with type 2 diabetes mellitus T2DM who started treatment with exenatide compared to those who started other glucose lowering drugs not including GLP-1 receptor agonists. This study uses retrospective data from multiple European countries collected from 2006 to 2023. Patients are matched by various factors to compare outcomes using an intention-to-treat approach. The study identifies two groups of patients those who initiated exenatide treatment and those who started other non-GLP-1 RA based glucose lowering drugs. Medication exposure is determined through prescription records or insurance claims available in eight data sources across seven countries. The follow-up period averages about 1.5 years or less, during which the occurrence of a primary diagnosis of pancreatic cancer is recorded and analyzed. Participants are not actively treated as part of the study but are observed through existing healthcare data. The main measurement is the incidence rate and hazard ratio of pancreatic cancer diagnosis during follow-up. Data includes medical histories, prescriptions, and diagnoses collected retrospectively. The study spans from 2024 to 2026 and aims to provide long-term safety information regarding exenatide use in T2DM patients.

This research aims to evaluate two different types of digital training programs supervised by physiotherapists compared to daily physical activity in adults with low back pain lasting more than three months. The study also seeks to determine if new MRI methods can detect changes in spine tissue over time and whether these changes differ depending on the type of exercise performed. Participants will be randomly assigned to one of three groups supervised digital training focused on core stability, supervised digital training focused on aerobic exercise, or a non-supervised daily physical activity program with regular physiotherapist support. Each group receives guidance and monitoring relevant to their assigned intervention. Throughout the study, participants will undergo clinical examinations, MRI scans, and complete patient-reported outcome measures at the start, 6 months, and 12 months. Researchers will assess changes in pain, clinical function, muscle condition, and psychological factors, alongside MRI-based tissue changes. This comprehensive follow-up helps track the impact of different exercise approaches on low back pain over one year.