Davos

The RECOVER study is an observational research project focused on patients undergoing cardiac rehabilitation at Hochgebirgsklinik Davos. It aims to understand patient characteristics, rehabilitation methods, recovery predictors, and clinical outcomes in heart disease patients, including those who have had cardiac procedures or surgeries. The study is sponsored by Medicine Campus Davos AG and the Khne Foundation, with a goal to identify factors that influence long-term recovery and improve individualized therapy. Participants will be patients referred for cardiac rehabilitation who provide informed consent. The study will create a detailed database and biobank for comprehensive patient profiling, including genetics, plasma, digital and clinical biomarkers, and comorbidities. It will follow patients over time to observe how these factors relate to their recovery and health outcomes. During the study, patients will undergo extensive clinical assessments and long-term follow-up at 1, 5, and 10 years after inclusion. Researchers will monitor cardiovascular events, hospitalizations, quality of life, cognitive function, and functional capacity. The study seeks to provide insights into modifiable risk factors and support better targeted rehabilitation approaches over a prolonged period.

Researchers are evaluating the effects of a digital lifestyle intervention on health-related quality of life HRQoL in survivors of non-small cell lung cancer NSCLC. Lung cancer survivors often experience ongoing symptoms like fatigue and breathing difficulties after treatment, which can lower their physical and psychological functioning. This study aims to support survivors beyond treatment by promoting physical activity, healthy eating, and breathing and relaxation exercises. Participants will be randomly assigned to either use a self-management mobile application focused on physical activity, nutrition, and breathingrelaxation for three months or receive usual care without changes to their planned treatments. The mobile app includes personalization and interactive features and one virtual appointment to help users get familiar with it and set appropriate goals. The intervention is based on behavior change techniques such as goal setting, feedback, and monitoring. Throughout the study, participants will be assessed on changes in overall and lung cancer-specific quality of life, physical activity, exercise capacity, psychological distress, fatigue, nutrition risks, and self-rated health over three months. Researchers will monitor these outcomes regularly to understand the interventions impact. The study period lasts three months, during which participants will complete questionnaires and other evaluations related to their health and well-being.

Severe asthma is a chronic disease marked by airway inflammation, varying airway obstruction, and different asthma types, affecting about 5% of asthma patients globally. Asthmas prevalence and impact on quality of life have increased despite better treatments, leading to frequent severe attacks and significant healthcare costs. This research aims to establish a multi-center clinical register for patients with severe asthma in Switzerland to improve understanding and management of this condition over time. The study collects data from patients with severe asthma treated at participating centers, including pulmonologists and hospital departments. Patients will be enrolled continuously and followed for up to 15 years, with regular assessments at baseline, after four months, and yearly thereafter. Some patients receiving specific therapies like antibodies may have a reduced data set recorded, with follow-up evaluations to monitor therapy response. No additional examinations beyond routine care are required. Participants will undergo regular evaluations including symptom control tests, lung function tests such as Forced Vital Capacity and Forced Expiratory Volume, quality of life questionnaires, blood analyses, and documentation of exacerbations and healthcare utilization. Data collection focuses on understanding symptom changes, asthma control, medication adjustments, and long-term outcomes. The study involves ongoing monitoring without additional patient procedures beyond normal clinical care.