Davos

The RECOVER study focuses on patients undergoing cardiac rehabilitation at the Hochgebirgsklinik Davos. It is a prospective, non-interventional cohort study aiming to evaluate patient characteristics, rehabilitation methods, recovery predictors, and clinical outcomes in heart disease patients, including those who have had cardiac procedures or surgeries. The study also seeks to understand how genetics, biomarkers, and comorbidities affect long-term recovery and to find modifiable risk factors for personalized therapy. Participants referred for cardiac rehabilitation at Hochgebirgsklinik Davos who provide informed consent will be enrolled. The study will build a detailed database and biobank to support comprehensive clinical assessments and long-term follow-up. The research team includes specialists from Medicine Campus Davos and Hochgebirgsklinik Davos. The study is planned to start in July 2025 and continue until December 2034, with possible extensions. During the study, researchers will track important outcomes such as cardiovascular death, heart attacks, strokes, hospitalizations for heart failure, and all-cause rehospitalizations after cardiac interventions or surgeries. Follow-up assessments will be done at 1, 5, and 10 years after enrollment. Participants will undergo extensive evaluations, including clinical exams and collection of biological samples, to monitor recovery and health status over time.

Non-small cell lung cancer (NSCLC) survivors often experience ongoing physical and psychological challenges, including fatigue and breathing difficulties, which reduce their overall health-related quality of life (HRQoL). This research evaluates whether a digital lifestyle intervention can improve HRQoL in these survivors over three months. The study focuses on enhancing physical activity, nutrition, and breathing or relaxation practices through a mobile application designed specifically for NSCLC survivors. Participants in the intervention group will receive access to a personalized and interactive mobile app for three months after completing rehabilitation or cancer treatment. The program includes behavior change techniques such as goal setting, feedback, knowledge shaping, and behavior comparison. A single virtual session at the start helps participants familiarize themselves with the app and sets their program level. There are no face-to-face appointments during the intervention period. Throughout the study, researchers will monitor participants' health-related quality of life from the start until three months later. Participants must have access to a smartphone or tablet and understand German to follow the study materials and assessments. Data collection includes self-reported outcomes via the app, and safety and participation are overseen by the study team. The total involvement lasts for the three-month intervention period after treatment or rehabilitation completion.

Asthma, a common chronic disease characterized by airway inflammation and variable airflow obstruction, affects about 2-8% of the population in Switzerland and approximately 300 million people worldwide. Despite advances in treatment, asthma prevalence and morbidity have increased, with severe asthma patients often facing frequent exacerbations and high healthcare costs. This study aims to establish a Swiss Severe Asthma Register to collect detailed data on patients with severe asthma, improving understanding of the disease's frequency, phenotypes, and treatment outcomes. The registry collects data from multiple respiratory centers across Switzerland, focusing on patients with severe asthma who require advanced therapies such as high-dose inhaled corticosteroids, systemic corticosteroids, or monoclonal antibody treatments. Participants are followed with baseline data collection and re-evaluated at four months and then annually for up to 15 years. Patients receiving new specific therapies are monitored with basic or full data profiles, enabling documentation and assessment of treatment responses over time. Participants undergo routine clinical assessments including lung function tests, laboratory values, and asthma control evaluations using tools like the Asthma Control Test. Follow-up visits repeat many parameters collected at baseline to track symptom control and treatment efficacy. The study continuously analyzes collected data to identify severe asthma subtypes and improve diagnostic evaluation and management strategies, with a goal to enhance patient care and optimize healthcare resource use.