Meyrin

Researchers are evaluating the functional outcomes of two types of shoulder replacement surgeries: anatomic total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (RTSA) for patients with primary glenohumeral osteoarthritis who have intact rotator cuffs and no significant glenoid bone loss or excessive glenoid retroversion. This prospective randomized study aims to determine if RTSA is at least as effective as anatomic TSA two years after surgery and also to explore if RTSA may provide superior clinical and radiographic results or fewer complications. Participants will receive either an anatomic or reverse shoulder prosthesis implanted to treat their primary glenohumeral arthritis. The study compares these devices in patients aged 65 to 85 years. Both groups will be monitored over a two-year postoperative period to assess outcomes. The treatment involves surgery to replace the shoulder joint with the designated prosthesis, followed by regular follow-up. During the study, participants will undergo assessments that include measuring the American Shoulder and Elbow Surgeons (ASES) score at baseline and two years after surgery to evaluate shoulder function and pain. Researchers will also monitor clinical and radiographic outcomes, postoperative complications, and overall recovery. Participants must provide informed consent and will be observed throughout the study period to ensure safety and compliance with study procedures.

Researchers are evaluating the effects of Sonodyn, an investigational handheld medical device, on adults suffering from therapy-resistant myofascial pain syndrome causing low back pain, tension headache, or neck pain. This chronic pain condition affects muscles or muscle groups and is a common cause of musculoskeletal pain and dysfunction. The study is a randomized, sham-controlled, double-blind, multi-center trial conducted in Austria and Switzerland to compare active Sonodyn therapy with a non-functional sham device. The Sonodyn device combines low-energy ultrasound, electrical, and magnetic field stimulation for non-invasive treatment by placing it over specific pain trigger points. Participants are randomized in a 2:1 ratio to receive either the active device that delivers stimulation or the sham device that looks identical but emits no signals. After a 1-week screening phase, patients use their assigned device three times daily for 10 minutes each over a 3-week treatment period, followed by an 8-week follow-up. During the study, participants report their average and maximum pain intensity twice daily using a Numeric Rating Scale (NRS) and record any use of rescue medication. The primary outcome measure is the average NRS pain score after 3 weeks. Researchers will assess differences between the active therapy and sham groups, correlating pain intensity changes with other pain-related scales. Total participation lasts 12 weeks, including screening, treatment, and follow-up.

This research evaluates anonymous, previously collected medical data to review the outcomes of different treatment methods for chronic pain. The study is a retrospective review involving multiple centers and independent patient groups to compare results across various subgroups. The study examines clinical outcomes related to the use of spinal cord stimulation, radiofrequency (RF), and other implantable device systems from Boston Scientific and other manufacturers. Multiple cohorts will be analyzed based on the type of treatment system used. Participants' medical charts will be reviewed to measure response rates through approximately two years of follow-up. The study focuses on clinical results documented in patient records without any new treatment or intervention administered during the study.

Researchers are evaluating treatment options for massive or irreparable rotator cuff tears, especially in people over 60 years old. The study compares two approaches: rotator cuff repair (RCR) and reverse shoulder arthroplasty (RSA). These tears are challenging to treat because healing rates after repair can be low and may lead to arthritis. RSA may reduce pain and improve shoulder function and quality of life. This prospective multicenter randomized trial aims to determine if there is a difference in functional outcomes between RCR and RSA for these patients. The treatments being studied include arthroscopic or open rotator cuff repair, where the torn tendon is reattached to bone using anchors and sutures, and reverse shoulder arthroplasty, which involves replacing the shoulder joint with a reverse design shoulder prosthesis. Both treatments are used for patients with massive, reparable rotator cuff tears who have not improved with conservative care. The study will evaluate these surgical procedures in a randomized fashion across multiple centers. Participants will be assessed through preoperative imaging including X-rays and MRI or arthro-MRI to confirm eligibility. Functional outcomes will be measured using the American Shoulder and Elbow Surgeon (ASES) score at 24 months post-operation. Throughout the study, researchers will monitor healing, shoulder function, pain, and quality of life. The study includes patients aged 60 to 80 years and involves detailed follow-up to compare the long-term results of the two surgical options.

Researchers are investigating treatments for shoulder pain and dysfunction caused by issues with the long head of the biceps (LHB) tendon in patients who have a tear in the supraspinatus tendon. The study aims to compare three approaches during rotator cuff repair surgery: LHB tenodesis (reattaching the tendon), LHB tenotomy (cutting the tendon), and leaving the LHB tendon intact. The goal is to determine which treatment provides better post-operative functional outcomes and to assess differences in complications and patient satisfaction among the three methods. Participants will be randomly assigned to one of three groups. The LHB tenotomy group will have the tendon cut arthroscopically at its origin using scissors. The LHB tenodesis group will undergo an arthroscopic procedure where the tendon is reattached at the top of the joint surface using an onlay technique. The third group will have the LHB tendon left intact during surgery. All patients will undergo rotator cuff repair for a full-thickness supraspinatus tear. Throughout the study, participants will be evaluated for their shoulder function using the ASES score at 24 months after surgery. Researchers will monitor recovery, complications, and patient satisfaction. Participants are expected to complete questionnaires and attend follow-up visits while complying with post-operative physical therapy. The study includes adults aged 50 to 80 who meet specific health and surgical criteria and will last at least two years to allow for full recovery and assessment.

Researchers are exploring a new approach to rehabilitation for common upper limb conditions such as shoulder instability, frozen shoulder, and rotator cuff tears. This study aims to test whether combining modern motion tracking and virtual reality (VR) can improve functional recovery by making therapy more engaging and tailored. The study focuses on a set of specially designed VR games that guide patients through physiotherapy exercises, hoping to boost motivation, track progress, and provide real-time feedback during treatment. Participants will take part in four physiotherapy sessions, each lasting 60 minutes, where part of the conventional exercises will be replaced by 30-minute VR-based sessions. During these sessions, patients will wear motion trackers on their arms and forearms, hold controllers in each hand, and wear a VR headset. Their real-world movements will control an avatar in the virtual environment, where exergames encourage them to perform therapeutic motions. A virtual coach will help prevent harmful movements and adjust exercise difficulty based on performance. Throughout the study, researchers will assess patient responses, including any symptoms of simulator sickness on the first day. The study will monitor how well patients engage with the VR sessions and measure improvements in mobility and strength. Participants will be evaluated to ensure they meet criteria such as the ability to consent and absence of conditions that could interfere with VR use. This feasibility study aims to determine if this gamified VR rehabilitation can be a valuable addition to traditional therapy.