Meyrin

Researchers are evaluating the functional outcomes of two types of shoulder replacement surgeriesanatomic total shoulder arthroplasty TSA and reverse total shoulder arthroplasty RTSAfor patients with primary glenohumeral osteoarthritis who have intact rotator cuffs and no significant glenoid retroversion. The study aims to determine if RTSA provides at least as good results as anatomic TSA and also to explore whether RTSA might lead to better clinical and radiographic outcomes with fewer complications. Participants will be randomly assigned to receive either an anatomic TSA or an RTSA through a deltopectoral surgical approach. Both procedures involve implanting a prosthesis designed to treat primary glenohumeral arthritis. The study compares these two surgical options over a follow-up period of two years. During the study, patients will be assessed using several measures including the American Shoulder and Elbow Surgeons ASES score, Subjective Shoulder Value SSV, range of motion, pain on a visual analog scale, Constant score, and Short Form-12 SF-12. Radiographic evaluations and complication rates will also be recorded over the two-year postoperative period. The total participation duration includes baseline assessment and follow-up evaluations spanning up to two years after surgery.

Researchers are evaluating the use of Sonodyn, an investigational handheld medical device, for adults suffering from therapy-resistant myofascial pain syndrome causing low back pain, tension headache, or neck pain. This condition is a common cause of muscle pain and dysfunction, characterized by trigger points in muscles. The study is a randomized, double-blind, sham-controlled trial conducted at multiple sites in Austria and Switzerland to assess the devices impact on pain levels. The study compares active Sonodyn therapy, which delivers low-energy ultrasound, electrical, and magnetic stimulation to targeted trigger points, with a sham device that looks identical but does not deliver any stimulation. Patients undergo treatment for three weeks, activating their assigned device three times daily for 10 minutes each session. The trial includes a one-week screening phase before treatment and an eight-week follow-up period after treatment, totaling 12 weeks of participation. Participants report their average and maximum pain intensity twice daily using a Numeric Rating Scale throughout screening, treatment, and follow-up periods. They also track the use of any rescue medication. Researchers will measure pain changes as the primary outcome and assess additional factors such as medication use, quality of sleep, and quality of life. The study monitors compliance and safety while comparing results between active therapy and sham control groups.

Researchers are reviewing anonymous medical records from multiple centers to understand the outcomes of different treatments for chronic pain. This study includes several groups to assess how various approaches work in distinct patient subgroups. The focus is on patients who have had or may have spinal cord stimulation systems or other treatments like radiofrequency RF or intradiscal therapies IDS. The study looks at patients who have previously received spinal cord stimulation or other therapies and those who have switched to different treatments afterward. Treatments under review include Boston Scientific devices and non-Boston Scientific systems such as spinal cord stimulation, RF, and IDS. The data is retrospective, meaning it examines past patient experiences without introducing new treatments. Participants involvement consists of the analysis of their de-identified medical charts, with no active treatment or visits required. Researchers will measure responder rates approximately two years from the start of data collection to evaluate treatment outcomes. The study spans from April 2012 to December 2030, focusing on long-term clinical results in chronic pain management.

Researchers are evaluating a wearable device designed to support balance and walking in adults with peripheral neuropathy. This trial aims to assess whether the device can improve gait stability and balance during daily activities while also examining its safety, comfort, and overall user acceptability. The study compares an active device with a sham inactive version in a controlled, randomized setting. Participants will be randomly assigned to use either the active wearable device or a sham device that lacks active functionality. They will use the device over a defined period to evaluate changes in gait and balance. The study includes weekly sessions and a home-use phase to monitor device performance and user experience. Both groups will be observed and assessed throughout the study to compare outcomes. Participants will attend weekly visits and perform home use of the device, with follow-up assessments up to 80 days. Researchers will measure changes in the Functional Gait Assessment score, timed-up-and-go test, neuropathic pain symptoms, quality of life, sensory function tests, fall risk, neuroimaging in some participants, and objective gait parameters like step length and heel-strike force. Treatment compliance and device usability will also be monitored to evaluate safety and effectiveness over the study period.

Researchers are comparing two surgical treatments for people aged 60 to 80 with massive, degenerative rotator cuff tears that have not improved with conservative care. The study aims to determine if there is a difference in shoulder function after treatment with either rotator cuff repair RCR or reverse shoulder arthroplasty RSA. This prospective multicenter randomized study addresses the challenges of healing in massive tears, which often have poor tissue and bone quality and may lead to arthritis progression. Participants will receive one of two treatments arthroscopic rotator cuff repair involves reattaching the torn tendon to the bone using anchors and sutures, while reverse shoulder arthroplasty replaces the shoulder joint with a reverse design prosthesis. Both approaches are performed surgically, and the study will compare their effects on shoulder function over time. During the study, participants will be monitored for up to 24 months after surgery with evaluations including the American Shoulder and Elbow Surgeon ASES score, pain levels, shoulder motion, and patient satisfaction. Researchers will also assess complications, tendon healing, prosthesis stability, and other shoulder-related outcomes. These assessments will help determine the functional benefits and risks associated with each treatment option.

Researchers are studying patients aged 50 to 80 with a full-thickness supraspinatus tendon tear to compare three treatments for the long head of the biceps LHB tendon, which may cause shoulder pain and dysfunction in rotator cuff problems. The study aims to find out if LHB tenodesis offers better functional outcomes after surgery compared to LHB tenotomy or leaving the tendon intact. The trial also looks at differences in complications and patient satisfaction among these approaches. Participants will be randomly assigned to one of three groups leaving the LHB tendon intact, performing an arthroscopic tenotomy where the tendon is cut at its origin, or performing an arthroscopic tenodesis where the tendon is cut and reattached using an onlay technique. All patients will undergo rotator cuff repair surgery. This study is conducted across multiple centers and uses a single-blind design to assess these surgical options. During the study, participants will be evaluated at various times, including 6 months and 24 months after surgery. Assessments include the ASES score, pain levels, shoulder function measures, tendon healing status, and any complications. Patient satisfaction and specific imaging findings related to the tendon and repair site will also be monitored. Follow-up will continue for up to two years to observe long-term outcomes and safety.

Researchers are investigating whether combining modern motion-tracking technology with virtual reality VR can improve rehabilitation outcomes for common upper limb conditions such as shoulder instability, frozen shoulder, and rotator cuff tears. The study aims to address challenges in traditional physiotherapy, where repetitive exercises can reduce patient motivation and adherence, potentially leading to less effective recovery. This feasibility study will explore if a gamified VR approach can enhance patient engagement and provide new ways to evaluate therapy progress. Participants will undergo four physiotherapy sessions, each lasting 60 minutes, where parts of conventional therapy are replaced by 30-minute VR exergame sessions. During these sessions, patients wear motion trackers on their arms and forearms, hold controllers, and use a commercial VR headset. Their real-world movements will control an avatar in virtual environments designed to guide them through therapeutic exercises. The VR system includes features like a virtual coach to prevent harmful movements, adaptive exercise difficulty, and continuous performance monitoring. Throughout the study, participants experience is assessed using questionnaires such as the Simulator Sickness Questionnaire, the Post-experimental Intrinsic Motivation Inventory, and the Avatar Embodiment Questionnaire. Patient satisfaction is also measured after the first day. Researchers will monitor movement quality, motivation, and safety during the sessions. The total participation includes four sessions, with detailed tracking of exercise performance and patient feedback to evaluate the feasibility of this personalized VR rehabilitation system.