Vitznau

Researchers are studying the brain activity related to walking and movement in people with Parkinson's disease to better understand the neural mechanisms involved. The study also seeks to find neural markers linked to gait that could help inspire personalized treatment options. It includes both healthy individuals and Parkinson's patients, focusing on differences in brain signals during movement tasks. Participants will take part in a single session lasting about 2.5 hours. During this time, brain activity will be recorded using EEG for all participants, while Parkinson's patients with implanted deep brain stimulation (DBS) electrodes will have additional recordings from these devices. Movement parameters such as gait patterns will be captured with motion capture, accelerometers, and electromyography. Parkinson's patients will also perform a brief neuromodulation task where they try to influence neural activity using mental strategies. Throughout the session, researchers will collect data on neural activity, muscle signals, and movement characteristics like gait symmetry and coordination. These measurements aim to identify specific brain activity patterns linked to walking in both groups. The study will monitor safety and participant compliance during the visit, which will last approximately 2.5 hours total.

Researchers are evaluating a high-dose, high-intensity (HDHI) neurorehabilitation program designed to improve functional outcomes for adults who have experienced a stroke. This study is part of the SwissNeuroRehab initiative, which aims to develop and assess innovative, technology-supported neurorehabilitation methods across various care settings in Switzerland. The focus is on understanding the feasibility and clinical impact of this HDHI therapy pathway in real-world inpatient, outpatient, and home environments for people in subacute and chronic stages after stroke. Participants will take part in a structured HDHI therapy program using CE-marked digital therapeutic devices such as MindMotion GO and Izar. The intervention is tailored to individual motor rehabilitation needs and delivered during inpatient rehabilitation lasting 4 to 6 weeks and/or home-based outpatient care lasting 8 to 12 weeks. Participants are expected to engage in about one hour of active, technology-supported training per day, five days a week, in addition to their standard rehabilitation care. Clinical teams trained in the HDHI protocol will supervise the therapy, providing ongoing support and monitoring progress throughout the treatment. During the study, participants will be assessed at baseline, discharge, and follow-up timepoints up to 12 to 15 months after enrollment. Researchers will collect standardized clinical assessments, patient-reported outcomes, rehabilitation records, and socioeconomic data. The main outcomes measured include adherence to the training schedule and participants' satisfaction with the program. Secondary outcomes explore preliminary clinical and functional changes and socioeconomic impacts. The total study duration allows for detailed monitoring of the intervention's feasibility and initial clinical effects across multiple Swiss rehabilitation centers.