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Diabetic foot is a serious complication of diabetes that can lead to ulceration, bone infections, and gangrene, often requiring surgical amputation or debridement. This research evaluates the outcomes of different anesthetic techniques used during diabetic foot amputations, specifically comparing peripheral nerve block (PNB) and general anesthesia. The study is a retrospective review of patient records from Ankara Bilkent City Hospital between 2021 and 2023, aiming to determine if PNB results in fewer postoperative complications, with the main focus on 30-day mortality after surgery and secondary outcomes including overall morbidity and hospital discharge timing. The study analyzes data from patients who had toe, ankle, or foot amputations due to diabetic foot. Anesthesia methods used include general anesthesia and peripheral nerve blocks, such as popliteal sciatic nerve blocks and, when needed, saphenous nerve blocks guided by ultrasound. The choice of anesthesia was based on clinical experience at the time of surgery. Detailed patient information collected includes demographics, preoperative medications, comorbidities, surgical details, and anesthesia type. Major complications such as pneumonia, heart attack, stroke, blood clots, kidney injury, and surgical site infections are monitored alongside pain ratings and length of surgery. Participants' medical records are reviewed for various health and treatment factors including smoking history, chronic diseases, and emergency surgery status. Researchers use statistical methods to explore the relationship between anesthesia type and postoperative outcomes, including survival rates and hospital stay lengths. The primary outcome measured is the 30-day mortality rate following amputation. Secondary outcomes involve assessing complications and hospital discharge duration. Results will help clarify the impact of anesthesia techniques on recovery and safety in diabetic foot amputation patients.