Hryanykivka

This research aims to gather long-term safety and effectiveness information for people treated with ibrutinib, a medicine taken by mouth that blocks a specific enzyme called brutons tyrosine kinase. The study focuses on participants who previously took part in ibrutinib studies that have finished and are still receiving ibrutinib treatment, continuing to benefit from it. It is an open-label study, meaning both participants and researchers know the treatment being given. Participants will continue taking ibrutinib capsules daily at the dose they were given in their prior study until the doctor decides the treatment is no longer helpful due to disease progression or side effects, the participant chooses to stop, other treatment options become available, or the study ends. Safety will be monitored throughout, and effectiveness data may be combined with previous study results. No formal testing of hypotheses is planned in this extension. During the study, participants will be regularly monitored for safety and disease status. The main outcome is the number of participants experiencing side effects within 30 days after the last ibrutinib dose or before starting another cancer therapy. Participants may continue treatment until alternative access to ibrutinib is arranged or the study ends, which is planned for December 2029. Researchers will collect ongoing data to understand the long-term effects of ibrutinib treatment.

Researchers are evaluating a brief mindfulness-based intervention compared to usual care for adults with chronic pain in Ukraine. This pragmatic randomized controlled trial aims to study the effects of a single 15-minute mindfulness session on pain intensity and related symptoms in patients attending a pain clinic. The study is sponsored by the University of Utah and focuses on practical treatment approaches in a real-world clinical setting. Participants receive either a 15-minute mindfulness intervention involving mindful breathing and awareness of pain sensations or 15 minutes of usual chronic pain care typically provided in an academic pain clinic. The mindfulness training is designed to enhance awareness and management of pain. The study compares these two approaches to understand their immediate effects. During participation, individuals will have their pain intensity measured before and 20 minutes after the intervention. Other assessments include changes in pain unpleasantness, positive feelings, desire for pain medication, anxiety, and depression. The study involves random assignment to groups without masking. Participants will be monitored during the brief intervention and outcome measurements to assess its effects on chronic pain symptoms.