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Found 2 Actively Recruiting clinical trials
Actively Recruiting
Researchers are evaluating treatments for children and young adults aged 9 to 14 who have a severe toothache caused by an inflamed nerve in a permanent lower back molar, a condition called symptomatic irreversible pulpitis. The study compares the comfort and effectiveness of a traditional root canal treatment alternative called pulpotomy, which removes only the infected part of the nerve while preserving the healthy tissue. The trial specifically investigates whether adding a gentle laser treatment to a modern dental filling material can reduce pain after the procedure. The study randomly assigns participants to one of two groups. The first group receives a full pulpotomy followed by sealing the tooth with EndoCem, a calcium silicate cement. The second group receives the same pulpotomy and EndoCem sealing, but additionally has the exposed nerve tissue treated with a low-level Er,Cr:YSGG laser. This laser is used in a non-contact mode to stimulate healing and reduce inflammation. Both groups receive treatment under blinded conditions to ensure unbiased results. Participants will record their pain levels using a visual analogue scale at 6, 12, 24, and 48 hours after the procedure to measure postoperative pain intensity. The study also monitors tooth condition, healing, and patient comfort. Researchers will analyze and compare pain scores between the two groups to see if the laser treatment improves recovery. The trial aims to provide evidence to help dentists optimize pulp-preserving treatments for severe toothache, making them more comfortable and effective.
Actively Recruiting
Healthy Volunteer
Researchers are evaluating the effectiveness of intentional replantation (IR) as a treatment for single-rooted teeth that are considered hopeless due to severe periodontic lesions. This study assesses changes in alveolar bone and periodontal tissues, symptom relief, and patient satisfaction and quality of life after the procedure. Cone beam computed tomography (CBCT) imaging is used to track radiographic changes at the start and 9 months after replantation, while clinical exams monitor symptoms such as pain, swelling, and tooth mobility. Participants undergo intentional replantation, which involves careful non-traumatic extraction of the affected tooth to preserve the periodontal ligament. The tooth is treated extraorally within 15 minutes, stored in a sterile medium, and granulation tissue is removed. Optional procedures such as root modifications or surface treatments may be performed before the tooth is replanted and stabilized with a non-rigid splint for 2 to 4 weeks. Postoperative care includes medications and chlorhexidine rinses, with follow-ups at 1 week, 4 weeks, and 9 months to evaluate healing, bone regeneration, and tooth viability. Participants are adults aged 18 to 70 with single-rooted teeth showing significant bone loss and mobility. Clinical and radiographic evaluations, as well as patient questionnaires, are completed at baseline and 9 months post-replantation. The primary outcome is the success of the IR procedure measured by tooth survival and periodontal healing. Secondary outcomes include patient-reported pain, function, and quality of life. Data will be analyzed by comparing pre- and post-treatment results to determine the procedure's effectiveness.