Palm Coast

Researchers are evaluating the Integrated Cancer Repository for Cancer Research (iCaRe2), a comprehensive multi-institutional resource developed by the Fred & Pamela Buffett Cancer Center. This resource collects and manages standardized, multi-dimensional, and longitudinal data and biospecimens from adult cancer patients, those at high risk, and normal controls. iCaRe2 includes data from a wide geographic area covering many small and rural hospitals and cancer centers, supporting studies on cancer risk factors, development, progression, and strategies for prevention, screening, early detection, and personalized treatment. iCaRe2 is a web-based, secure, HIPAA-compliant registry that integrates multiple specialized cancer collaborative registries covering a broad range of cancers such as pancreatic, breast, thyroid, thoracic, genitourinary, gastrointestinal, central nervous system, leukemia, gynecological, sarcoma, melanoma, and more. The system allows participating centers to contribute data and biospecimens like tumor samples, germ line DNA, serum, urine, and plasma. This flexible "confederation model" enables centers with different expertise and resources to collaborate on diverse research projects through a common platform. Participants include adult individuals aged 19 and older who have a cancer diagnosis or history, are at risk for cancer, have suspicious clinical findings, or have no history of cancer (normal controls). Data collection includes demographic, clinical, and biospecimen information. The registry supports multi-dimensional data mining and sharing to advance cancer research. The primary outcome is the ongoing development and implementation of this web-based cancer collaborative registry, with long-term data collection and collaboration planned over many years.