Nutley

Researchers are evaluating the safety of LEQEMBI in patients with Alzheimers disease in a real-world clinical setting. The study focuses on tracking specific events related to amyloid-related imaging abnormalities ARIA, including ARIA-edema ARIA-E, ARIA-hemosiderin deposition ARIA-H, symptomatic ARIA-E, symptomatic ARIA-H, and intracerebral hemorrhage larger than 1 centimeter. The aim is to gather safety data over a long period while patients receive LEQEMBI treatment. This is an observational, non-interventional study where patients with Alzheimers disease are treated with LEQEMBI according to the approved prescribing information by their physician during routine clinical practice. Data will be collected from the South Korean JOY-ALZ registry, which tracks patients receiving this treatment. There is no placebo or comparator group, and treatment decisions are made prior to enrollment. Participants will be followed for up to 6 years, during which researchers will monitor and record the incidence and rates of adverse events of special interest, including ARIA-related events and other adverse drug reactions. They will also observe serious adverse events and reactions. The study collects real-world data to better understand the safety profile of LEQEMBI over time in the South Korean population with Alzheimers disease.

Researchers are evaluating if a special intervention website called Mosaic can improve patient-reported outcomes for adults with blood cancers undergoing allogeneic or autologous stem cell transplants. This study compares the intervention website to an educational website to see if it reduces psychological distress, cancer treatment-related distress, physical symptoms, and improves quality of life. The study also explores if benefits vary by patients language, initial distress levels, sex, race, ethnicity, and transplant type. Participants are randomly assigned to use either the intervention website or a control website throughout the study. Both websites provide coping and stress management training, educational content, and links to trusted resources in English and Spanish. The intervention website additionally offers experiential transplant information and supports skill practice. Participants can access their assigned website before and after transplant during the study period. Participants complete five assessments one before transplant and four follow-ups at 2, 4, 6, and 8 months post-transplant. Researchers measure changes in psychological distress, cancer treatment-related distress, symptoms, and health-related quality of life. The study monitors how patients use the websites and examines factors related to improvements. The entire study is expected to continue until 2030 with ongoing data collection and analysis.