Nutley

Researchers are assessing the safety of LEQEMBI in patients with Alzheimer's Disease in a real-world clinical setting. The study focuses on monitoring specific side effects related to brain imaging abnormalities, such as edema and hemorrhage, in individuals treated with LEQEMBI. This postmarketing study aims to gather safety data over an extended period to better understand the risks associated with LEQEMBI treatment. This is a non-interventional study, meaning that there is no experimental treatment or placebo given as part of the study. Participants are those who have already been prescribed LEQEMBI as part of their routine clinical care. The study collects real-world data from patients enrolled in the South Korean JOY-ALZ registry, which tracks Alzheimer's treatment and diagnostics. Participants provide written consent for their medical information to be shared and monitored over a period of up to six years. Researchers will track the incidence and rates of adverse events of special interest related to LEQEMBI use, including amyloid-related imaging abnormalities and intracerebral hemorrhage. The study's long-term follow-up helps to understand the safety profile of LEQEMBI in everyday clinical practice.

Researchers are evaluating whether using a special intervention website called Mosaic can improve patient-reported outcomes for adults with blood cancers who are undergoing allogeneic or autologous stem cell transplants. This trial compares the intervention website to a control educational website. The study focuses on improvements in psychological distress, cancer treatment-related distress, physical symptoms, and health-related quality of life, while also exploring how factors like language, initial distress, sex, race, ethnicity, and transplant type may affect benefits. Participants will be randomly assigned to use either the intervention website, which offers experiential information, stress and coping resources, educational content, and links to trusted psychosocial resources, or the control website, which provides stress and coping resources, educational content, and similar links. They will use their assigned website throughout the study period. Participants will complete five assessments: one before their transplant and four follow-ups at 2, 4, 6, and 8 months after transplant. Researchers will measure improvements in general psychological distress and other patient-reported outcomes over time. The study involves adult patients proficient in English or Spanish who are preparing for or scheduled to undergo stem cell transplant. The total study duration includes baseline and multiple post-transplant evaluations to monitor changes and benefits.