Zuni

Researchers are investigating chronic kidney disease (CKD) and cardiovascular disease (CVD) in American Indians (AIs) in the Southwestern US to understand unique risk factors and disease progression in this population. This observational study builds upon the parent CRIC study and aims to improve knowledge of CKD and CVD burden among AIs by using updated protocols and measurements. Participants will undergo a baseline clinic visit where weight, blood pressure, heart rate, medical history, and medication use are recorded. Blood and urine samples are collected to assess kidney and heart function. The Ankle Brachial Index (ABI) is measured, and participants complete questionnaires on quality of life, diet, mood, thinking, and physical activity. Follow-up telephone contact occurs six months later to check on medical events and medications. Annual visits will repeat many of these assessments. Additionally, participants may join one of two substudies involving remote data collection to study kidney function and cardiovascular risk over time. The main measure of interest is the slope of kidney function decline over five years. Secondary outcomes include onset of end stage renal disease, significant loss of renal function, and changes in protein levels in urine. Participants are monitored regularly through clinic visits and phone calls for up to five years. A specimen bank will be established to support future research on biomarkers related to CKD progression in AIs. The total study duration spans several years, with ongoing evaluations to track kidney and heart health.