Bloomsburg

Researchers are evaluating the real-world clinical impact of the Galleri4, a blood-based multi-cancer early detection MCED test, in a Medicare population aged 50 years and older. This multi-center prospective cohort study aims to assess the tests safety and performance alongside usual care, enrolling participants representative of Medicare beneficiaries. The study is observational and compares outcomes between those receiving the Galleri test plus usual care and those receiving usual care alone. Participants in the Galleri-tested arm will have blood collected for the MCED test with results returned to guide further evaluation. The comparator group consists of Medicare beneficiaries receiving usual care without the Galleri test. Both groups will be observed over a period of up to 3 years to evaluate cancer incidence and diagnostic outcomes. Throughout the study, researchers will monitor the incidence of stage IV cancers, the number and types of invasive procedures following test results, adherence to recommended cancer screening, and healthcare resource use related to cancer diagnostics. Safety and test performance will be tracked in the Galleri-tested group. Participation involves routine clinical visits and data collection for up to 3 years, with no interventions withheld for either group.

Researchers are investigating whether Osteopathic Manipulative Therapy OMT, specifically the lymphatic pump technique, can help reduce symptoms and shorten the duration of respiratory illnesses such as upper respiratory illness, sinusitis, bronchitis, and pneumonia. This study focuses on patients aged 65 to 100 years and evaluates if adding OMT to standard care can improve patient outcomes compared to standard care alone. Respiratory illnesses commonly cause discomfort, reduced productivity, and missed work, and OMT is a low-cost treatment used to support immune response and fluid movement. Participants will be randomly assigned to one of two groups one receiving standard care alone, which may include medications and follow-up instructions, and the other receiving standard care plus the lymphatic pump OMT. This OMT procedure involves manual pressure and physical stimulation over various body regions such as the head, neck, thoracic, lumbar, sacral, pelvis, arms, legs, and abdomen to stimulate immune response and help clear infections. The study will take place in an outpatient setting, with patients being treated and monitored accordingly. During the study, participants will complete electronic surveys on the day of diagnosis and five days later to report symptoms like cough, congestion, and overall malaise. These symptom reports will be securely stored and analyzed to assess changes in severity and illness duration. The primary goal is to determine how much the lymphatic pump OMT can improve symptoms and reduce sickness length when added to standard care. The study will follow participants for up to one year, with careful monitoring of symptom progression and treatment effects.

Researchers are comparing the rates of surgical and minimally invasive interventions, as well as any harms, in Medicare beneficiaries treated with the MILD procedure versus those treated with interspinous process decompression IPD for lumbar spinal stenosis with neurogenic claudication. This observational study uses Medicare claims data to follow patients for 24 months after their initial procedure starting from January 1, 2017. The purpose is to evaluate outcomes between these two types of procedures without requiring prior patient enrollment or consent. The study includes two groups patients who received MILD, which is a percutaneous image-guided lumbar decompression performed under fluoroscopic guidance through a dorsal approach to the spine, and patients who received IPD, a different device-based decompression procedure. Data on reoperations and complications will be collected for both groups over a 24-month follow-up period using Medicare claims. Enrollment continues until the sponsor decides to stop. Participants involvement is passive as the study uses existing Medicare claims data. Researchers will monitor rates of harms related to the initial procedure and subsequent surgical or minimally invasive interventions over two years. No direct patient visits or interventions are conducted, and the study is exempt from institutional review board oversight. The total study duration extends to December 2026, covering cases treated since early 2017.