Actively Recruiting
REACH Study: Galleri® Multi-Cancer Early Detection Test in Medicare Population
Led by GRAIL, Inc. · Updated on 2026-05-22
50000
Participants Needed
61
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the real-world clinical impact of the Galleri4, a blood-based multi-cancer early detection (MCED) test, in a Medicare population aged 50 years and older. This multi-center prospective cohort study aims to assess the test's safety and performance alongside usual care, enrolling participants representative of Medicare beneficiaries. The study is observational and compares outcomes between those receiving the Galleri test plus usual care and those receiving usual care alone. Participants in the Galleri-tested arm will have blood collected for the MCED test with results returned to guide further evaluation. The comparator group consists of Medicare beneficiaries receiving usual care without the Galleri test. Both groups will be observed over a period of up to 3 years to evaluate cancer incidence and diagnostic outcomes. Throughout the study, researchers will monitor the incidence of stage IV cancers, the number and types of invasive procedures following test results, adherence to recommended cancer screening, and healthcare resource use related to cancer diagnostics. Safety and test performance will be tracked in the Galleri-tested group. Participation involves routine clinical visits and data collection for up to 3 years, with no interventions withheld for either group.
CONDITIONS
Brief Title
Galleri® in the Medicare Population.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 50 years or older with Medicare coverage (Traditional Medicare Part A & B, Dual Eligibles, or Medicare Advantage)
- Able to provide legally effective informed consent (not via legally authorized representative)
- For Galleri-tested arm: Medicare beneficiaries receiving Galleri test plus usual care
- For usual care arm: Medicare beneficiaries with at least one usual care visit
You will not qualify if you...
- Prior multi-cancer early detection test (including Galleri, CancerSeek, PanSeer), except participation in certain studies without returned results
- Undergoing clinical evaluation for suspected cancer within 6 months before enrollment
- Personal history of hematologic malignancy or invasive solid tumor unless non-metastatic basal or squamous cell skin cancer, with specific timing and treatment restrictions
- Currently undergoing active cancer treatment (excluding certain hormone therapies)
- Current pregnancy
- Currently inpatient at a participating site
- Not willing or able to comply with protocol procedures
- Not currently registered at a participating center
- Past or current employee or contractor of GRAIL (for Galleri-tested arm only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 years
Participants undergo blood collection and multi-cancer early detection testing with return of results, or usual care without additional intervention. Medicare beneficiaries who receive routine care are observed over time for cancer incidence and diagnostic evaluations.
Periodic visits depending on usual care and follow-up assessments
Trial Site Locations
Total: 61 locations
1
Mercy Health - Fort Smith
Fort Smith, Arkansas, United States, 72903
Actively Recruiting
2
Sutter Valley Hospitals Auburn
Auburn, California, United States, 95603
Actively Recruiting
3
Sutter Valley Hospitals Davis
Davis, California, United States, 95616
Actively Recruiting
4
Sutter Valley Hospitals Elk Grove
Elk Grove, California, United States, 95758
Actively Recruiting
5
Long Beach Memorial Orange Coast
Fountain Valley, California, United States, 92708
Actively Recruiting
6
Long Beach Memorial Saddleback
Laguna Hills, California, United States, 92653
Actively Recruiting
7
Long Beach Memorial Atlantic
Long Beach, California, United States, 90806
Actively Recruiting
8
Sutter Valley Hospitals Modesto
Modesto, California, United States, 95355
Actively Recruiting
9
Sutter Valley Hospitals PAMF Sutter
Palo Alto, California, United States, 94301
Actively Recruiting
10
Sutter Valley Hospitals Roseville
Roseville, California, United States, 95661
Actively Recruiting
11
Sutter Valley Hospitals Alhambra
Sacramento, California, United States, 95816
Actively Recruiting
12
Sutter Valley Hospitals Capitol Pavilion
Sacramento, California, United States, 95816
Actively Recruiting
13
University of California San Francisco Health System
San Francisco, California, United States, 94158
Actively Recruiting
14
Sutter Valley Hospitals Santa Barbara
Santa Barbara, California, United States, 93105
Actively Recruiting
15
Sutter Valley Hospitals PAMF Santa Cruz
Santa Cruz, California, United States, 95065
Actively Recruiting
16
Sutter Health Santa Rosa
Santa Rosa, California, United States, 95403
Actively Recruiting
17
Sutter Valley Hospitals PAMF Sunnyvale
Sunnyvale, California, United States, 94086
Actively Recruiting
18
Sutter Valley Hospitals Fairfield
Vallejo, California, United States, 94589
Actively Recruiting
19
USF Morsani Center for Advanced Healthcare
Tampa, Florida, United States, 33612
Actively Recruiting
20
Morehouse School of Medicine Atlanta
Atlanta, Georgia, United States, 30303
Actively Recruiting
21
Morehouse School of Medicine Lee Street
Atlanta, Georgia, United States, 30310
Actively Recruiting
22
Morehouse School of Medicine Princeton Lakes
Atlanta, Georgia, United States, 30331
Actively Recruiting
23
Morehouse School of Medicine East Point
Atlanta, Georgia, United States, 30344
Actively Recruiting
24
HCA Healthcare Doctors Hospital
Augusta, Georgia, United States, 30909
Actively Recruiting
25
Community Health Network Anderson
Anderson, Indiana, United States, 46011
Actively Recruiting
26
Community Health Network North
Fishers, Indiana, United States, 46038
Actively Recruiting
27
Community Health Network East
Indianapolis, Indiana, United States, 46219
Actively Recruiting
28
Community Health Network South
Indianapolis, Indiana, United States, 46256
Actively Recruiting
29
Community Health Network Kokomo
Kokomo, Indiana, United States, 46902
Actively Recruiting
30
Community Health Network LaFountain
Kokomo, Indiana, United States, 46902
Actively Recruiting
31
Ochsner Health Bocage
Baton Rouge, Louisiana, United States, 70809
Actively Recruiting
32
Ochsner Health Grove
Baton Rouge, Louisiana, United States, 70836
Actively Recruiting
33
Ochsner Health Covington
Covington, Louisiana, United States, 70433
Actively Recruiting
34
Ochsner Health St. Tammany Parish
Covington, Louisiana, United States, 70433
Actively Recruiting
35
Ochsner Health STCC
Covington, Louisiana, United States, 70433
Actively Recruiting
36
Ochsner Health Kenner
Kenner, Louisiana, United States, 70065
Actively Recruiting
37
Ochsner Health Lafayette
Lafayette, Louisiana, United States, 70503
Actively Recruiting
38
Ochsner Health Westbank
Marrero, Louisiana, United States, 70072
Actively Recruiting
39
Ochsner Health Lafreniere
Metairie, Louisiana, United States, 70003
Actively Recruiting
40
Ochsner Health Baptist
New Orleans, Louisiana, United States, 70115
Actively Recruiting
41
Ochsner Health Benson
New Orleans, Louisiana, United States, 70121
Actively Recruiting
42
Mercy Health - Springfield
Springfield, Missouri, United States, 65807
Actively Recruiting
43
Mercy Health St. Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
44
OHSU CEDAR Clinical Trials Columbia
Astoria, Oregon, United States, 97103
Actively Recruiting
45
OHSU CEDAR Clinical Trials Exchange
Astoria, Oregon, United States, 97103
Actively Recruiting
46
OHSU CEDAR Clinical Trials Beaverton
Beaverton, Oregon, United States, 97006
Actively Recruiting
47
OHSU CEDAR Clinical Trials Orenco
Hillsboro, Oregon, United States, 97124
Actively Recruiting
48
OHSU CEDAR Clinical Trials Woods
Hood River, Oregon, United States, 97031
Actively Recruiting
49
OHSU CEDAR Clinical Trials Portland
Portland, Oregon, United States, 97201
Actively Recruiting
50
OHSU CEDAR Clinical Trials Richmond
Portland, Oregon, United States, 97202
Actively Recruiting
51
OHSU CEDAR Clinical Trials Adventist
The Dalles, Oregon, United States, 97058
Actively Recruiting
52
OHSU CEDAR Clinical Trials Dalles
The Dalles, Oregon, United States, 97058
Actively Recruiting
53
OHSU CEDAR Clinical Trials Ensign
Warrenton, Oregon, United States, 97146
Actively Recruiting
54
Geisinger Bloomsburg Hospital - Bloomsburg
Bloomsburg, Pennsylvania, United States, 17815
Actively Recruiting
55
HCA Healthcare Brentwood
Brentwood, Tennessee, United States, 37027
Actively Recruiting
56
HCA Healthcare Centennial
Nashville, Tennessee, United States, 37203
Actively Recruiting
57
HCA Healthcare Nashville
Nashville, Tennessee, United States, 37203
Actively Recruiting
58
HCA Healthcare St. Marks
Salt Lake City, Utah, United States, 84124
Actively Recruiting
59
West Virginia University Health System St. Joseph
Buckhannon, West Virginia, United States, 26201
Actively Recruiting
60
West Virginia University Health System Morgantown
Morgantown, West Virginia, United States, 26501
Actively Recruiting
61
West Virginia University Health System WV CTSI
Morgantown, West Virginia, United States, 26506
Actively Recruiting
Research Team
G
GRAIL Medical Information
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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