Actively Recruiting
Longitudinal Sexual and Reproductive Health Study of Women With Breast Cancer and Lymphoma
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-04
475
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how cancer treatments affect sexual and reproductive health in women diagnosed with breast cancer or lymphoma. This observational study aims to understand the prevalence, severity, timing, and factors related to sexual dysfunction in both premenopausal and postmenopausal women. The study also explores how treatments impact fertility and decisions about fertility preservation over a five-year period. Participants will complete detailed surveys on sexual function at several points: before starting chemotherapy, then at 3, 6, and 12 months after baseline, and yearly thereafter for up to five years. A subset of premenopausal women on Tamoxifen will also undergo blood draws and transvaginal ultrasounds at specified intervals to assess ovarian function. Blood samples and ultrasounds are optional but help evaluate the biological effects of treatment on fertility. Women will be asked to complete questionnaires related to sexual health and reproductive concerns, with follow-up surveys administered by mail or phone if needed. The study measures the natural history of sexual and reproductive health changes over five years, including predictors of dysfunction and comparisons between breast cancer and lymphoma patients. Participants' safety and health data will be monitored throughout, and involvement may last up to five years.
CONDITIONS
Brief Title
Longitudinal Sexual and Reproductive Health Study of Women With Breast Cancer and Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female, 18 years of age or older
- Premenopausal women at diagnosis who have been pregnant or had at least one menstrual period in the last 12 months, or have had an intrauterine device (IUD) in place in the last 12 months
- Newly diagnosed breast cancer (stage 0-III) within 1 month of starting systemic treatment or aggressive lymphoma treated with first line curative therapy
- Breast cancer patients of any receptor type
- English speaking
- Able to participate in the informed consent process
- For Tamoxifen-only subset: planning to start Tamoxifen as only systemic treatment within one month
- Postmenopausal women at diagnosis who have not had a period for 2 or more years
You will not qualify if you...
- Active secondary cancer requiring cytotoxic chemotherapy
- Prior systemic treatment for any malignancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants complete surveys at baseline and at multiple follow-up points to assess sexual and reproductive health over time.
Surveys at baseline, 3 months, 6 months, 1 year, and yearly for 5 years
Duration - Up to 2 years
Participants in specific cohorts provide blood samples at scheduled intervals to support study assessments.
Blood draws at baseline, 6 months, 12 months, and 24 months
Duration - 6 months
Premenopausal participants receiving Tamoxifen undergo transvaginal ultrasounds to evaluate ovarian reserve.
Transvaginal ultrasounds at baseline and 6 months
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Commack
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
S
Shari Goldfarb, MD
J
Jeanne Carter, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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