Study of Low-Dose Total Skin Electron Therapy Using Rotisserie Technique for Patients With Refractory or Relapsed Stage IB-IIIA Mycosis Fungoides

What this Trial Is About

Researchers are evaluating low-dose total skin electron therapy using the rotisserie technique in patients with stage IB-IIIA mycosis fungoides that has not responded to previous treatments or has returned after improvement. This approach uses radiation to target tumor cells on the skin, aiming to reduce side effects and allow for repeated treatments if needed. The study focuses on assessing quality of life, treatment response durability, and side effects. Participants receive low-dose total skin electron therapy daily for under one hour from days 10 to 21 while standing on a rotating platform. Quality of life is measured using the Skindex-29 questionnaire, and skin response is graded using the modified Severity-Weight Assessment mSWAT tool. After treatment, patients are followed up at 6 and 12 weeks, then every 3 months to monitor ongoing effects and any disease changes. During the study, patients complete questionnaires and undergo physical examinations by a radiation oncologist to assess skin condition and treatment impact. Researchers track changes in quality of life and skin lesion severity over up to three years. Side effects of the therapy are also monitored throughout this period. The total participation time varies with follow-up continuing until disease changes are observed.

Low-Dose Total Skin Electron Therapy in Treating Patients With Refractory or Relapsed Stage IB-IIIA Mycosis Fungoides