Actively Recruiting
Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation
Led by Radboud University Medical Center · Updated on 2025-01-13
100
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
Sponsors
R
Radboud University Medical Center
Lead Sponsor
S
Solve FSHD
Collaborating Sponsor
AI-Summary
What this Trial Is About
Facioscapulohumeral dystrophy (FSHD) is one of the most common hereditary neuromuscular disorders (NMD), with an estimated prevalence of 2000 patients in the Netherlands. Magnetic resonance imaging (MRI) and muscle ultrasound have contributed to an enhanced understanding of the pathophysiology of Facioscapulohumeral Muscular Dystrophy (FSHD). Previously, our group demonstrated the potential presence of an intermediate factor between muscle fiber loss and clinical weakness in FSHD. The influence of disrupted muscle architecture in FSHD on muscle contractile efficiency is a likely candidate for this factor, and remains relatively unexplored. In this study, we aim to assess the use of ultrasound-defined contractile performance, in comparison with current measures including structural MRI, for monitoring disease progression in FSHD.
CONDITIONS
Official Title
Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years.
- Informed consent is given by the participant.
- Ability to read and understand written and spoken instruction in Dutch.
- Willingness and ability to understand nature and content of the study
You will not qualify if you...
- Body mass index of 35 or higher.
- Other diseases that affect muscle integrity or imaging beyond expected.
- Wheelchair dependence.
- Pregnancy.
- Contraindications for MRI including claustrophobia, pacemakers or defibrillators, nerve stimulators, intracranial clips, intraorbital or intraocular metallic fragments, cochlear or ferromagnetic implants, inability to lie still for 60 minutes, need for continuous daytime ventilation, or scoliosis surgery.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Radboud university medical center
Nijmegen, Gelderland, Netherlands
Actively Recruiting
Research Team
O
Odette Van Iersel, MSc
CONTACT
J
Jonne Doorduin, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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