Actively Recruiting
Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease
Led by Centre Hospitalier Intercommunal Creteil · Updated on 2025-09-02
186
Participants Needed
4
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Centre Hospitalier Intercommunal Creteil
Lead Sponsor
H
Henri Mondor University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the regenerative abilities of mesenchymal cells in the environment surrounding alveolar type 2 cells in patients undergoing thoracic surgery for suspected cancer. The study focuses on comparing smokers (including those with and without chronic obstructive pulmonary disease, COPD) to non-smokers. COPD and emphysema involve damage to lung cells that repair alveoli, and the study aims to better understand how these cells and their interactions change with smoking and disease. Participants will undergo thoracic resection surgery, such as pneumonectomy, lobectomy, or segmentectomy, as part of their cancer or suspected cancer treatment. The study includes smokers (active or former) and non-smokers, both with and without COPD. Researchers will analyze lung tissue samples collected during surgery to assess cell populations and their characteristics. During the study, participants will be followed for up to five years after surgery, with yearly assessments of emphysema severity and type. Researchers will measure various outcomes, including the number of alveolar organoids, fibroblast behavior, signaling pathways in lung cells, tumor progression, and lung function tests such as FEV1, FVC, DLCO, and KCO. Biomarkers in blood and intestinal microbiota will also be studied to better understand disease mechanisms and progression.
CONDITIONS
Brief Title
Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patient undergoing lung resection surgery (lobectomy, pneumonectomy, segmentectomy) for cancer or suspected cancer
- Willing to participate in the study protocol
- Affiliated with a social security plan
You will not qualify if you...
- Having a chronic autoimmune disease
- Under legal guardianship or curatorship
- Receiving neo-adjuvant chemotherapy
- History of thoracic radiotherapy
- Pregnant woman
- Minor patient
- Unable to provide informed consent
- Deprived of liberty
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and immediate recovery period
Participants undergo thoracic resection surgery such as pneumonectomy, lobectomy, or segmentectomy for cancer or suspected cancer, including smokers and non-smokers with or without COPD, followed by immediate post-operative care.
1 surgery visit and hospital stay
Duration - Up to 3 years
Participants are monitored for up to 3 years to study alveolar cell characteristics, pulmonary function, biomarkers, and disease progression including pulmonary emphysema severity and tumor progression.
Visits at inclusion and annually for up to 5 years post-surgery
Trial Site Locations
Total: 4 locations
1
Rousseau-Bussac
Créteil, France, 94000
Actively Recruiting
2
Hopital Cochin
Paris, France, 75014
Active, Not Recruiting
3
HEGP
Paris, France, 75015
Active, Not Recruiting
4
Hopital Tenon
Paris, France, 75020
Active, Not Recruiting
Research Team
J
JUNG Camille, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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