Advancing perioperative prediction of cardiac risk after vascular surgery: does postoperative N-terminal pro-brain natriuretic peptide do the trick?
John Augoustides, Lee A Fleisher
https://pubmed.ncbi.nlm.nih.gov/17525578Actively Recruiting
Age: 18Years +
All Genders
ID04014647
Peri-operative Measurement of NT-proBNP to Predict Outcomes in Patients Undergoing Elective Vascular Surgery
Led by Norfolk and Norwich University Hospitals NHS Foundation Trust · Updated on 2026-06-08
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether measuring N-terminal pro B-type natriuretic peptide (NT-proBNP) and other heart-related markers can help predict outcomes for patients undergoing elective major vascular surgery. The study aims to identify high-risk patients who may face serious complications like heart attacks or death after surgery. Understanding these risks could help guide treatments to improve patient care and long-term health. This observational study measures NT-proBNP levels before and four days after surgery. It also tracks other markers such as troponin I, galectin-3, CRP, and creatinine during the same peri-operative period. Patients are grouped based on whether they experience negative events post-surgery, including cardiac events, infections, kidney issues, or extended hospital stays. Participants will have blood tests at specified times around surgery and be monitored for various clinical events within 31 days after surgery. The study collects data on hospital stay length, use of antibiotics, inotropic support, and kidney alerts. Researchers aim to use these measurements to better predict patient outcomes and potentially guide future interventions for improved recovery and survival.
CONDITIONS
Brief Title
Measurement Of NT-proBNP to Predict Outcomes in Surgery
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients who are equal to or over 18 years old
- Patients scheduled to undergo elective surgery for infrainguinal arterial reconstruction
- Patients scheduled to undergo elective surgery for aortic aneurysm
- Patients scheduled to undergo elective surgery for aorto-bifemoral bypass or aortic endarterectomy
- Patients scheduled to undergo elective surgery for femoro-popliteal bypass
- Patients scheduled to undergo elective surgery for femoro-distal bypass
- Patients scheduled to undergo elective surgery for femoral endarterectomy
- Patients scheduled to undergo elective surgery for femoro-femoral crossover
- Patients scheduled to undergo elective surgery for axillo-femoral bypass
- Patients scheduled to undergo elective carotid surgery
- Patients having either general or regional anaesthesia for their surgery
You will not qualify if you...
- Patients undergoing emergency surgery
- Patients unable or unwilling to give informed consent
- Patients with unstable coronary syndromes including recent myocardial infarction or severe angina
- Patients with decompensated heart failure with new or worsening symptoms
- Patients with chronic atrial fibrillation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - Day of surgery and up to 4 days post-surgery
Participants undergo elective vascular surgery with measurement of cardiac biomarkers before and shortly after surgery to assess risk.
1 baseline visit on the day of surgery and 1 visit 4 days after surgery
Long-term Monitoring
Duration - Up to 31 days after surgery
Participants are observed for cardiovascular events and other negative outcomes within 31 days following surgery.
Follow-up assessments as part of routine care
Trial Site Locations
Total: 1 location
1
Norfolk & Norwich University Hospitals NHS Foundation Trust
Norwich, Norfolk, United Kingdom, NR4 7UY
Actively Recruiting
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Research Team
E
Emma Miler, MSc BSc Hons
A
Allison Chipchase, Dr
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Vascular surgery patients: perioperative and long-term risk according to the ACC/AHA guidelines, the additive role of post-operative troponin elevation.
Francesca Bursi, Luciano Babuin, Andrea Barbieri...
https://pubmed.ncbi.nlm.nih.gov/16055493Attitudes to outcomes measured in clinical trials of cardiovascular prevention.
M Canavan, A Smyth, S M Robinson...
https://pubmed.ncbi.nlm.nih.gov/26231089Plasma N-terminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery.
Harm H H Feringa, Olaf Schouten, Martin Dunkelgrun...
https://pubmed.ncbi.nlm.nih.gov/16914484N-terminal pro-brain natriuretic peptide identifies patients at high risk for adverse cardiac outcome after vascular surgery.
Elisabeth Mahla, Anneliese Baumann, Peter Rehak...
https://pubmed.ncbi.nlm.nih.gov/17525582Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure.
Roland R van Kimmenade, James L Januzzi, Patrick T Ellinor...
https://pubmed.ncbi.nlm.nih.gov/16979009Preoperative plasma N-terminal pro-brain natriuretic peptide as a marker of cardiac risk in patients undergoing elective non-cardiac surgery.
H-M Yeh, H-P Lau, J-M Lin...
https://pubmed.ncbi.nlm.nih.gov/15997451