Actively Recruiting
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
Led by Washington University School of Medicine · Updated on 2026-03-23
100
Participants Needed
1
Research Sites
300 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.
CONDITIONS
Official Title
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to less than 40 years
- Body mass index (BMI) between 18.5 and less than 25.0 kg/m2
- Baseline LDL cholesterol less than 150 mg/dL (less than 3.9 mmol/L)
- Baseline triglycerides less than 100 mg/dL (less than 1.1 mmol/L)
- HbA1c of 5.6% or lower
You will not qualify if you...
- Personal or family history of familial hypercholesterolemia
- Current use of lipid-lowering drugs
- Currently following a ketogenic diet and unwilling to change
- Current tobacco use
- Hypertension
- Prediabetes or diabetes
- Elevated Lp(a) greater than 6.5% of ApoB-containing lipoproteins at baseline
- Use of oral contraceptives
- Contraindication to heparin
- Known atherosclerotic cardiovascular disease
- Unwillingness to abstain from alcohol
AI-Screening
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Trial Site Locations
Total: 1 location
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
F
Frannie Wilkinson, M.A.
CONTACT
M
Max C Petersen, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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