Actively Recruiting
Mechanisms And Prognosis of Stroke-Heart Syndrome
Led by Chensheng Pan · Updated on 2025-05-01
658
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
C
Chensheng Pan
Lead Sponsor
N
National Natural Science Foundation of China
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating stroke-heart syndrome, a condition that often occurs after an acute stroke, including both ischemic stroke and intracerebral hemorrhage. This syndrome is linked with higher death rates and worse recovery outcomes, but its causes are not well understood. The study aims to clarify the neuro-humoral mechanisms behind this syndrome using advanced brain imaging and comprehensive blood analyses. It also plans to track how stroke-heart syndrome develops and affects patients' functional abilities, thinking skills, and emotional health after stroke. The research hopes to identify new blood markers and brain mechanisms to guide future treatments and prevention strategies, while developing an early warning system for serious heart complications after stroke to improve patient care.
CONDITIONS
Brief Title
Mechanisms And Prognosis of Stroke-Heart Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients admitted within 48 hours of stroke onset confirmed by CT or MRI
- Adults aged 18 years or older
- Moderate to severe stroke with NIHSS score of 5 or higher
You will not qualify if you...
- Previous focal brain injury such as stroke, brain surgery, or traumatic brain injury
- Brain dysfunction caused by other major neurological disorders like brain tumors, epilepsy, or Parkinson's disease
- Transient ischemic attack (TIA) or subarachnoid hemorrhage (SAH)
- History of cardiac diseases including coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, or valvular heart disease
- Concomitant systemic diseases such as severe kidney failure, autoimmune disorders, or severe infections
- History of dementia, depression, or other psychiatric disorders
- Poor compliance or inability to cooperate with follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 48 hours after stroke onset
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 1 week after stroke onset
Participants undergo blood tests and cardiac imaging to assess heart function following stroke.
2 visits (in-person) within 1 week
Duration - Up to 1 year after stroke onset
Participants are observed for functional outcomes, cognitive and emotional health, and survival over time following stroke.
3 visits at 1 month, 3 months, and 1 year (in-person or remote)
Trial Site Locations
Total: 1 location
1
Department of Neurology, Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030
Actively Recruiting
Research Team
C
Chensheng Pan, M.D.
Z
Zhou Zhu, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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