Actively Recruiting
Study of Microdialysis and Tissue Sampling in Diabetic and Non-Diabetic Patients Undergoing Non-Traumatic Above-Knee Amputation
Led by University of Aarhus · Updated on 2026-02-12
20
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating the microenvironment of the amputation stump in patients undergoing non-traumatic transfemoral amputation, focusing on ischemia, inflammation, and antibiotic presence. The study compares diabetic and non-diabetic patients to better understand local tissue conditions after surgery. Participants will be randomly assigned to one of two groups receiving different wound care treatments after amputation. One group will receive closed incision negative pressure wound therapy ciNPWT, while the other will receive standard stump dressing SSD. The study measures ischemia within 72 hours after surgery. During the trial, patients will have microdialysis and tissue sampling performed to analyze the local stump environment. Researchers will monitor ischemia and collect data within the first three days post-operation. Participation involves assessments related to wound healing and local tissue status, with follow-up continuing until study completion in 2028.
CONDITIONS
Brief Title
Microenvironment in Patients Undergoing Non-traumatic Amputation
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