MRI Screening in Men at High Risk of Developing Prostate Cancer

What this Trial Is About

Researchers are investigating whether Magnetic Resonance Images MRI can detect high-grade prostate cancers earlier and more often in men who have a high risk of developing prostate cancer. The study focuses on men with different levels of genetic risk, including those with known gene mutations, high genetic risk scores, family history of prostate cancer, or low genetic risk. The research evaluates the role of MRI and genetic risk scores in screening men at elevated risk for prostate cancer. Participants will undergo MRI scans enhanced with gadolinium, an intravenous contrast agent used to improve imaging of the prostate. The study compares baseline prostate MRI results among men with various genetic risk factors and family histories to those without identifiable risk. The trial includes four groups based on germline mutations, genetic risk scores, family history, and low-risk status. During the study, participants will have prostate MRI scans every three years for up to 15 years. Researchers will monitor how often high-grade prostate cancer is detected through these screenings. The study team will also evaluate safety concerns related to gadolinium use and collect medical information related to prostate cancer diagnosis. Participation involves long-term follow-up with regular imaging to assess prostate health and cancer detection over time.

MRI Screening in Men at High Risk of Developing Prostate Cancer