Actively Recruiting
Multicentre Study Analysing Wastewater to Monitor Bacterial Resistance to Antibiotics in Residential Care Homes for Elderly Dependent
Led by Nantes University Hospital · Updated on 2026-04-16
1600
Participants Needed
2
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how common antibiotic-resistant bacteria, specifically extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenemase-producing Enterobacterales (CPE), are among residents in nursing homes and how these bacteria relate to their presence in the wastewater from these facilities. The study addresses the challenge of current surveillance systems that mainly use clinical samples and may miss widespread bacteria carriage in long-term care settings. It focuses on improving detection and prevention of outbreaks within healthcare networks. The study monitors nursing home residents by collecting stool samples or rectal swabs to measure the prevalence of these resistant bacteria. At the same time, wastewater discharged from the nursing homes is tested for the amount of ESBL-PE and CPE or their resistance genes. The main goal is to build a model that links the bacteria found in residents with the levels found in wastewater over a 15-month period. Participants will be evaluated through sample collection and their health and cognitive status assessed to ensure informed non-opposition to participation. Researchers will analyze the predictive accuracy of their model in estimating bacteria carriage. The study will also track the epidemiology of ESBL-PE and CPE in nursing homes, with no intervention applied. The total observation period for outcome measures spans 15 months, and participation involves sample collection and data recording during this time.
CONDITIONS
Brief Title
A Multicentre Study of Wastewater and Antibiotic Resistance in Care Homes.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Residents present on the day of sampling (D0 or D+1) in a randomly selected nursing home facility
- Residents whose health status allows participation on the day of the survey
- Residents with MMSE score 20 or higher who can understand the study and express informed non-opposition
- Residents unable to provide informed non-opposition but with a legal representative, trusted person, or loved one to provide it
- Residents may participate regardless of infection, diarrheal stools, antibiotic use, other treatments, or health status
- Participants may be concurrently enrolled in other research projects
You will not qualify if you...
- Facilities not classified as nursing homes (e.g., FAM, MAS)
- Residents whose health status is incompatible with study procedures on the survey day (e.g., end-of-life with comfort care)
- Residents with MMSE score 20 or less, or without MMSE but unable to provide informed non-opposition and without a legal representative or trusted person
- Residents who refuse sample collection on the day of the survey, regardless of MMSE score
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 15 months
Participants provide stool or rectal swab samples to assess bacterial carriage of antibiotic-resistant organisms.
Sampling visits at the time of wastewater collection
Duration - 15 months
Participants are observed while wastewater is collected and analyzed to model bacterial resistance prevalence in the facility.
Ongoing wastewater sampling coordinated with participant sampling
Trial Site Locations
Total: 2 locations
1
CHU d'Angers
Angers, France, 49100
Actively Recruiting
2
CHU de Nantes
Nantes, France, 44093
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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