Actively Recruiting
Multimodal Bio-mechanical Analysis of Adult Spinal Deformity With Sagittal Plane Misalignment
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-03-13
265
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying adult spinal deformities with sagittal plane misalignment to better understand how balance and neuromuscular control affect posture and movement. The study explores how the trunk, pelvis, and lower limbs work together in people with spinal deformities, especially during standing and walking. Current diagnostic methods focus on static imaging, but this research aims to provide a dynamic evaluation to improve understanding of compensatory mechanisms and postoperative complications. The study compares different groups of adults: those with decompensated sagittal misalignment, compensated misalignment, no sagittal misalignment, and healthy controls without spinal deformities. Various analyses such as 2D versus 3D EOS stereo radiographic imaging, static versus dynamic evaluations, and pre- versus postoperative assessments will be performed. Researchers will also assess muscle activity using dynamic electromyography and test the reliability of movement and balance evaluation methods. Participants will undergo clinical balance tests, 3D motion analysis, and radiographic evaluations over a follow-up period of up to 2 years. Outcomes measured include health-related quality of life, physical activity, and detailed motion analysis to understand dynamic function and compensatory patterns. Additional assessments include cognitive and performance scores and fall risk evaluations. The study involves regular follow-up visits to complete questionnaires and attend imaging and motion analysis sessions.
CONDITIONS
Brief Title
Multimodal Bio-mechanical Analysis of Adult Spinal Deformity With Sagittal Plane Misalignment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 45 to 79 years
- Diagnosis of adult congenital, degenerative, idiopathic, or iatrogenic spinal deformity (pathological group)
- Scoring at least 25 out of 30 on Mini Mental State Examination (pathological group)
- Ability to walk at least 50 meters independently without walking aid (pathological group)
- Sagittal malalignment or coronal malalignment as defined by specific spinal measurement criteria (pathological group)
- Ability and willingness to attend follow-up visits and complete questionnaires
- Completed informed consent
- Asymptomatic adults without spinal deformity, age 45 or older (control group)
- Scoring at least 27 out of 30 on Mini Mental State Examination (control group)
- Ability to walk at least 1000 meters independently without walking aid (control group)
You will not qualify if you...
- Age below 45 years
- Absence of adult spinal deformity (pathological group)
- Scoring less than 25 out of 30 on Mini Mental State Examination (pathological group)
- Inability to walk at least 50 meters independently, with or without walking aid (pathological group)
- Missing informed consent
- Neurological diseases affecting balance other than Parkinson's disease, such as stroke or vestibular lesions
- Current diagnosed musculoskeletal disorders affecting trunk or lower limbs motor performance, such as severe hip, knee, or ankle arthrosis, or leg length discrepancy greater than 3 cm
- Body mass index over 30 (pathological group)
- Back pain or sciatica at time of study (control group)
- Presence of spinal deformity leading to pathological sagittal alignment (control group)
- Scoring less than 27 out of 30 on Mini Mental State Examination (control group)
- Inability to walk at least 1000 meters independently without walking aid (control group)
- Body mass index over 27 (control group)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 years
Participants undergo a combination of static and dynamic analyses including EOS stereo radiographic imaging, clinical postural tests, and instrumented movement analysis to evaluate spinal deformity and compensation mechanisms.
Multiple visits over 2 years for assessments and measurements
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Actively Recruiting
Research Team
L
Lieven Moke
L
Lennart Scheys
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
4
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