Actively Recruiting

Age: 60Years +
All Genders
NCT03998202

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Led by Wake Forest University Health Sciences · Updated on 2026-01-08

300

Participants Needed

146

Research Sites

379 weeks

Total Duration

On this page

Sponsors

W

Wake Forest University Health Sciences

Lead Sponsor

U

University of Alabama at Birmingham

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.

CONDITIONS

Official Title

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Who Can Participate

Age: 60Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Newly diagnosed metastatic colorectal cancer or newly recognized metastatic recurrence of colorectal cancer at least 3 months (12 weeks) after finishing treatment for non-metastatic colorectal cancer
  • Planning to start or recently started first-line immunotherapy and/or 5-FU based chemotherapy (alone or combined with oxaliplatin and/or irinotecan, with or without immunotherapy); capecitabine is allowed
  • Estimated life expectancy of 6 months or more
  • Able to understand English or Spanish to complete questionnaires
  • Willing and able to sign a written informed consent
  • Eligibility does not depend on BMI or weight; patients with significant weight change (more than ±10%) in the past 12 months are eligible
Not Eligible

You will not qualify if you...

  • Currently enrolled in hospice care
  • Prior systemic chemotherapy for metastatic colorectal cancer (adjuvant chemotherapy completed at least 3 months before recurrence and treatment is allowed)
  • Receiving any other investigational agents
  • Untreated brain metastases (patients with treated brain metastases are eligible)
  • Currently on or planned to undergo radiation therapy in the near future

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 146 locations

1

Beebe South Coastal Health Campus

Millville, Delaware, United States, 19967

Actively Recruiting

2

Helen F Graham Cancer Center

Newark, Delaware, United States, 19713

Actively Recruiting

3

Medical Oncology Hematology Consultants PA

Newark, Delaware, United States, 19713

Actively Recruiting

4

Beebe Health Campus

Rehoboth Beach, Delaware, United States, 19971

Actively Recruiting

5

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, United States, 19801

Actively Recruiting

6

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, United States, 20007

Actively Recruiting

7

John B Amos Cancer Center

Columbus, Georgia, United States, 31904

Actively Recruiting

8

Illinois CancerCare-Bloomington

Bloomington, Illinois, United States, 61704

Actively Recruiting

9

Illinois CancerCare-Canton

Canton, Illinois, United States, 61520

Actively Recruiting

10

SIH Cancer Institute

Carterville, Illinois, United States, 62918

Actively Recruiting

11

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, United States, 60612

Actively Recruiting

12

Carle at The Riverfront

Danville, Illinois, United States, 61832

Actively Recruiting

13

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, United States, 62526

Actively Recruiting

14

Crossroads Cancer Center

Effingham, Illinois, United States, 62401

Actively Recruiting

15

Illinois CancerCare-Galesburg

Galesburg, Illinois, United States, 61401

Actively Recruiting

16

Carle Physician Group - Mattoon/Charleston

Mattoon, Illinois, United States, 61938

Actively Recruiting

17

SSM Health Good Samaritan

Mount Vernon, Illinois, United States, 62864

Actively Recruiting

18

Carle BroMenn Medical Center

Normal, Illinois, United States, 61761

Actively Recruiting

19

Carle Cancer Institute Normal

Normal, Illinois, United States, 61761

Actively Recruiting

20

Cancer Care Center of O'Fallon

O'Fallon, Illinois, United States, 62269

Actively Recruiting

21

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, United States, 61350

Actively Recruiting

22

Illinois CancerCare-Pekin

Pekin, Illinois, United States, 61554

Actively Recruiting

23

Illinois CancerCare-Peoria

Peoria, Illinois, United States, 61615

Actively Recruiting

24

Illinois CancerCare-Peru

Peru, Illinois, United States, 61354

Actively Recruiting

25

Southern Illinois University School of Medicine

Springfield, Illinois, United States, 62702

Actively Recruiting

26

Springfield Clinic

Springfield, Illinois, United States, 62702

Actively Recruiting

27

Carle Cancer Center

Urbana, Illinois, United States, 61801

Actively Recruiting

28

Illinois CancerCare - Washington

Washington, Illinois, United States, 61571

Actively Recruiting

29

The University of Iowa - Ankeny

Ankeny, Iowa, United States, 50023

Actively Recruiting

30

Saint Anthony Regional Hospital

Carroll, Iowa, United States, 51401

Actively Recruiting

31

Physicians' Clinic of Iowa PC

Cedar Rapids, Iowa, United States, 52402

Actively Recruiting

32

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, United States, 52403

Actively Recruiting

33

UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, United States, 50325

Actively Recruiting

34

Iowa Methodist Medical Center

Des Moines, Iowa, United States, 50309

Actively Recruiting

35

The University of Iowa-Des Moines

Des Moines, Iowa, United States, 50309

Actively Recruiting

36

Broadlawns Medical Center

Des Moines, Iowa, United States, 50314

Actively Recruiting

37

Mercy Medical Center - Des Moines

Des Moines, Iowa, United States, 50314

Actively Recruiting

38

UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, United States, 50314

Actively Recruiting

39

UI Healthcare Mission Cancer and Blood - Fort Dodge

Fort Dodge, Iowa, United States, 50501

Actively Recruiting

40

Saint Joseph Hospital East

Lexington, Kentucky, United States, 40509

Withdrawn

41

Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, United States, 70809

Actively Recruiting

42

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, United States, 70809

Actively Recruiting

43

MBP Cancer Center - Baton Rouge General

Baton Rouge, Louisiana, United States, 70809

Actively Recruiting

44

Terrebonne General Medical Center

Houma, Louisiana, United States, 70360

Actively Recruiting

45

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, United States, 48106

Actively Recruiting

46

Trinity Health IHA Medical Group Hematology Oncology-Brighton

Brighton, Michigan, United States, 48114

Actively Recruiting

47

Trinity Health Medical Center-Brighton

Brighton, Michigan, United States, 48114

Actively Recruiting

48

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, United States, 48188

Actively Recruiting

49

Trinity Health Medical Center - Canton

Canton, Michigan, United States, 48188

Actively Recruiting

50

Chelsea Hospital

Chelsea, Michigan, United States, 48118

Actively Recruiting

51

Trinity Health IHA Hematology Oncology Consultants-Chelsea Hospital

Chelsea, Michigan, United States, 48118

Actively Recruiting

52

Cancer Hematology Centers - Flint

Flint, Michigan, United States, 48503

Actively Recruiting

53

Genesee Hematology Oncology PC

Flint, Michigan, United States, 48503

Actively Recruiting

54

Genesys Hurley Cancer Institute

Flint, Michigan, United States, 48503

Actively Recruiting

55

Marshfield Medical Center Dickinson

Iron Mountain, Michigan, United States, 49801

Actively Recruiting

56

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, United States, 48154

Actively Recruiting

57

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, United States, 48341

Actively Recruiting

58

Corewell Health Reed City Hospital

Reed City, Michigan, United States, 49677

Actively Recruiting

59

University of Michigan Health - West

Wyoming, Michigan, United States, 49519

Actively Recruiting

60

Trinity Health IHA Medical Group Hematology Oncology -Ann Arbor

Ypsilanti, Michigan, United States, 48197

Actively Recruiting

61

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, United States, 56601

Actively Recruiting

62

Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, United States, 56401

Actively Recruiting

63

Mercy Hospital

Coon Rapids, Minnesota, United States, 55433

Actively Recruiting

64

Essentia Health - Deer River Clinic

Deer River, Minnesota, United States, 56636

Actively Recruiting

65

Essentia Health Saint Mary's - Detroit Lakes Clinic

Detroit Lakes, Minnesota, United States, 56501

Actively Recruiting

66

Essentia Health Cancer Center

Duluth, Minnesota, United States, 55805

Actively Recruiting

67

Fairview Southdale Hospital

Edina, Minnesota, United States, 55435

Actively Recruiting

68

Essentia Health Hibbing Clinic

Hibbing, Minnesota, United States, 55746

Actively Recruiting

69

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, United States, 55109

Actively Recruiting

70

Saint John's Hospital - Healtheast

Maplewood, Minnesota, United States, 55109

Actively Recruiting

71

Abbott-Northwestern Hospital

Minneapolis, Minnesota, United States, 55407

Actively Recruiting

72

Health Partners Inc

Minneapolis, Minnesota, United States, 55454

Withdrawn

73

New Ulm Medical Center

New Ulm, Minnesota, United States, 56073

Actively Recruiting

74

Essentia Health - Park Rapids

Park Rapids, Minnesota, United States, 56470

Actively Recruiting

75

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, United States, 55416

Actively Recruiting

76

Regions Hospital

Saint Paul, Minnesota, United States, 55101

Actively Recruiting

77

United Hospital

Saint Paul, Minnesota, United States, 55102

Actively Recruiting

78

Essentia Health Sandstone

Sandstone, Minnesota, United States, 55072

Actively Recruiting

79

Saint Francis Regional Medical Center

Shakopee, Minnesota, United States, 55379

Actively Recruiting

80

Essentia Health Virginia Clinic

Virginia, Minnesota, United States, 55792

Actively Recruiting

81

Rice Memorial Hospital

Willmar, Minnesota, United States, 56201

Actively Recruiting

82

Saint Francis Medical Center

Cape Girardeau, Missouri, United States, 63703

Actively Recruiting

83

Parkland Health Center - Farmington

Farmington, Missouri, United States, 63640

Actively Recruiting

84

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, United States, 65401

Withdrawn

85

Heartland Regional Medical Center

Saint Joseph, Missouri, United States, 64506

Actively Recruiting

86

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, United States, 63670

Actively Recruiting

87

Mercy Hospital Springfield

Springfield, Missouri, United States, 65804

Actively Recruiting

88

CoxHealth South Hospital

Springfield, Missouri, United States, 65807

Actively Recruiting

89

Missouri Baptist Medical Center

St Louis, Missouri, United States, 63131

Actively Recruiting

90

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, United States, 63080

Actively Recruiting

91

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, United States, 63127

Actively Recruiting

92

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, United States, 28203

Actively Recruiting

93

Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, United States, 28210

Actively Recruiting

94

Levine Cancer Institute-SouthPark

Charlotte, North Carolina, United States, 28211

Actively Recruiting

95

Atrium Health University City/LCI-University

Charlotte, North Carolina, United States, 28262

Actively Recruiting

96

Wake Forest University at Clemmons

Clemmons, North Carolina, United States, 27012

Actively Recruiting

97

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, United States, 28025

Actively Recruiting

98

Levine Cancer Institute-Gaston

Gastonia, North Carolina, United States, 28054

Actively Recruiting

99

Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, North Carolina, United States, 28659

Actively Recruiting

100

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

101

Sanford Bismarck Medical Center

Bismarck, North Dakota, United States, 58501

Actively Recruiting

102

Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, United States, 58103

Actively Recruiting

103

Sanford Broadway Medical Center

Fargo, North Dakota, United States, 58122

Actively Recruiting

104

Sanford Roger Maris Cancer Center

Fargo, North Dakota, United States, 58122

Actively Recruiting

105

Adena Regional Medical Center

Chillicothe, Ohio, United States, 45601

Actively Recruiting

106

The Mark H Zangmeister Center

Columbus, Ohio, United States, 43219

Actively Recruiting

107

Armes Family Cancer Center

Findlay, Ohio, United States, 45840

Actively Recruiting

108

Knox Community Hospital

Mount Vernon, Ohio, United States, 43050

Actively Recruiting

109

Licking Memorial Hospital

Newark, Ohio, United States, 43055

Actively Recruiting

110

Southern Ohio Medical Center

Portsmouth, Ohio, United States, 45662

Actively Recruiting

111

Springfield Regional Cancer Center

Springfield, Ohio, United States, 45504

Actively Recruiting

112

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, United States, 43701

Actively Recruiting

113

Geisinger Medical Center

Danville, Pennsylvania, United States, 17822

Actively Recruiting

114

Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, United States, 18201

Actively Recruiting

115

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, United States, 17837

Actively Recruiting

116

Lewistown Hospital

Lewistown, Pennsylvania, United States, 17044

Actively Recruiting

117

Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, United States, 17901

Actively Recruiting

118

Community Medical Center

Scranton, Pennsylvania, United States, 18510

Actively Recruiting

119

Geisinger Medical Oncology-Selinsgrove

Selinsgrove, Pennsylvania, United States, 17870

Actively Recruiting

120

Geisinger Medical Group

State College, Pennsylvania, United States, 16801

Actively Recruiting

121

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, United States, 18711

Actively Recruiting

122

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, United States, 29316

Actively Recruiting

123

Prisma Health Cancer Institute - Easley

Easley, South Carolina, United States, 29640

Actively Recruiting

124

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, United States, 29341

Actively Recruiting

125

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, United States, 29605

Actively Recruiting

126

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, United States, 29605

Actively Recruiting

127

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, United States, 29615

Actively Recruiting

128

Self Regional Healthcare

Greenwood, South Carolina, United States, 29646

Withdrawn

129

Prisma Health Cancer Institute - Greer

Greer, South Carolina, United States, 29650

Actively Recruiting

130

Gibbs Cancer Center-Pelham

Greer, South Carolina, United States, 29651

Actively Recruiting

131

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, United States, 29672

Actively Recruiting

132

Spartanburg Medical Center

Spartanburg, South Carolina, United States, 29303

Actively Recruiting

133

MGC Hematology Oncology-Union

Union, South Carolina, United States, 29379

Actively Recruiting

134

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, United States, 57104

Actively Recruiting

135

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States, 57117-5134

Actively Recruiting

136

Duluth Clinic Ashland

Ashland, Wisconsin, United States, 54806

Actively Recruiting

137

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, United States, 54701

Actively Recruiting

138

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, United States, 54301

Actively Recruiting

139

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, United States, 54303

Actively Recruiting

140

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, United States, 54449

Actively Recruiting

141

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, United States, 54548

Actively Recruiting

142

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, United States, 54868

Actively Recruiting

143

Essentia Health-Spooner Clinic

Spooner, Wisconsin, United States, 54801

Actively Recruiting

144

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, United States, 54482

Actively Recruiting

145

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, United States, 54235-1495

Actively Recruiting

146

Marshfield Medical Center - Weston

Weston, Wisconsin, United States, 54476

Actively Recruiting

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Research Team

K

Karen Craver

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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