Actively Recruiting
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
Led by Hospital do Coracao · Updated on 2026-05-08
1211
Participants Needed
27
Research Sites
N/A
Total Duration
On this page
Sponsors
H
Hospital do Coracao
Lead Sponsor
I
Instituto Nacional de Cardiologia de Laranjeiras
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are developing a registry of Brazilian patients with hereditary cardiovascular diseases by combining clinical information and genetic data. The study aims to identify which genes are most commonly affected and the frequency of these genetic changes within this population. The registry will help advance understanding and healthcare for hereditary heart conditions in Brazil's public health system. Participants will be interviewed during their routine medical visits, and their DNA will be collected using buccal swabs for whole genome sequencing. This observational study does not involve any treatment but focuses on gathering detailed genetic and clinical data to better characterize hereditary cardiovascular diseases. The study is planned to run for 30 months starting from April 2025. During the study, participants will provide information through interviews and give DNA samples for sequencing. Researchers will measure diagnostic yield, genetic diversity, and variant frequency over the 30 months. The study does not involve additional interventions beyond data and sample collection, and participants will continue their usual medical care throughout the study period.
CONDITIONS
Brief Title
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
- Agree to receive genetic counseling
- Sign informed consent form
- Provide the information required in the case report form
You will not qualify if you...
- Signature absent from informed consent form
- Inadequate buccal swab (sample may be collected twice)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 30 months
Participants provide buccal swab samples for whole genome sequencing to assess hereditary cardiovascular diseases.
1 to 2 visits for sample collection
Duration - Up to 30 months
Participants are observed over time to monitor genetic diversity and variant frequency related to cardiovascular hereditary diseases.
Periodic visits depending on individual follow-up needs
Trial Site Locations
Total: 27 locations
1
Centro de Pesquisa Silvestre Santé
Rio Branco, Acre, Brazil, 69915-030
Actively Recruiting
2
Centro de Pesquisas Clínicas Dr. Marco Mota
Maceió, Alagoas, Brazil, 57051-160
Actively Recruiting
3
Hospital Universitário da Unifap
Macapá, Amapá, Brazil, 68903-419
Actively Recruiting
4
Hospital de Messejana Dr. Carlos Alberto Studart Gomes
Fortaleza, Ceará, Brazil, 60840-285
Actively Recruiting
5
Hospital Evangélico de Vila Velha
Vila Velha, Espírito Santo, Brazil, 29118-060
Actively Recruiting
6
Hospital Universitário Professor Edgard Santos
Salvador, Estado de Bahia, Brazil, 40110-060
Actively Recruiting
7
Hospital Ana Nery - HAN/SESAB
Salvador, Estado de Bahia, Brazil, 40320-010
Actively Recruiting
8
Instituto de Cardiologia e Transplantes do Distrito Federal
Brasília, Federal District, Brazil, 70675-731
Actively Recruiting
9
Hospital das Clínicas da Universidade Federal de Goiás - HC-UFG
Goiânia, Goiás, Brazil, 74605-050
Actively Recruiting
10
Hospital Felicio Rocho - HFR
Belo Horizonte, Minas Gerais, Brazil, 30110-934
Actively Recruiting
11
Liga Mineira de Ressuscitação Cardiopulmonar
Belo Horizonte, Minas Gerais, Brazil, 30130-110
Actively Recruiting
12
Santa Casa de Misericórdia de Montes Claros
Montes Claros, Minas Gerais, Brazil, 39401-001
Actively Recruiting
13
Health & Care
Belém, Pará, Brazil, 66093-055
Actively Recruiting
14
Hospital Universitário Pedro Ernesto - UERJ
Rio de Janeiro, Rio de Janeiro, Brazil, 20551-030
Actively Recruiting
15
Instituto de Puericultura e Pediatria Martagão Gesteira
Rio de Janeiro, Rio de Janeiro, Brazil, 21941-912
Actively Recruiting
16
Hospital Universitário Clementino Fraga Filho - UFRJ
Rio de Janeiro, Rio de Janeiro, Brazil, 21941-913
Actively Recruiting
17
Instituto Nacional de Cardiologia
Rio de Janeiro, Rio de Janeiro, Brazil, 22240-006
Actively Recruiting
18
Hospital Universitário Onofre Lopes - UFRN
Natal, Rio Grande do Norte, Brazil, 59012-300
Actively Recruiting
19
Hospital das Clínicas de Porto Alegre - UFRGS
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
Actively Recruiting
20
Instituto de Cardiologia - Fundação Universitária de Cardiologia de Porto Alegre - IC-FUC
Porto Alegre, Rio Grande do Sul, Brazil, 90040-370
Actively Recruiting
21
Instituto de Pesquisa e Ensino em Saúde - IPES
Porto Velho, Rondônia, Brazil, 76801-098
Actively Recruiting
22
Centro Multidisciplinar de Ensino Especializado e Pesquisa Ltda
Joinville, Santa Catarina, Brazil, 89204-250
Actively Recruiting
23
Hospital Universitário São Francisco na Providência de Deus, USF-SP
Bragança Paulista, São Paulo, Brazil, 12916-542
Actively Recruiting
24
Instituto PENSI
Consolação, São Paulo, Brazil, 01228-200
Actively Recruiting
25
Hospital Universitário da Universidade Federal de São Carlos
São Carlos, São Paulo, Brazil, 13566-448
Actively Recruiting
26
Hospital do Coracao
São Paulo, São Paulo, Brazil, 04004-030
Actively Recruiting
27
Universidade Federal do Tocantins
Palmas, Tocantins, Brazil, 77001-090
Actively Recruiting
Research Team
A
Adriana Bastos Carvalho, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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