Actively Recruiting
Led by PROspective Renal Cancer Cohort Foundation · Updated on 2025-06-06
2000
Participants Needed
27
Research Sites
N/A
Total Duration
P
PROspective Renal Cancer Cohort Foundation
Lead Sponsor
C
Comprehensive Cancer Centre The Netherlands
Collaborating Sponsor
Researchers are conducting a nationwide long-term study called PRO-RCC to collect real-world clinical data, patient-reported outcome measures (PROMs), and patient-reported experience measures (PREMs) for patients with renal cell carcinoma (RCC), including both localized and metastatic forms. This study also provides a framework to conduct additional observational and randomized interventional studies within the cohort using a Trial within Cohorts (TwiCs) design. The study gathers clinical data embedded in the Netherlands Cancer Registry and collects PROMs related to health-related quality of life and optional return-to-work questionnaires, as well as PREMs regarding satisfaction with care. These data are collected online through the PROFILES registry and are accessible to both patients and their treating physicians. Participants may also agree to take part in randomized studies within the cohort. Participants will be monitored for up to five years, with primary outcomes including survival, disease progression, and patient-reported outcomes collected over this period. Secondary outcomes include patient-reported adverse events over two years. The study involves regular collection of questionnaires and clinical data, supporting both observational research and interventional trials within the established cohort.
CONDITIONS
National PROspective Infrastructure for Renal Cell Carcinoma (PRO-RCC)
You may qualify if you...
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 5 years
Participants with localized or metastatic renal cell carcinoma are observed with clinical data collection and patient-reported outcome measures over time.
Data collection occurs through online questionnaires and registry data; visit frequency varies based on routine clinical care and participant consent
Total: 27 locations
1
Amsterdam UMC locatie VUMC
Amsterdam, North Holland, Netherlands
Actively Recruiting
2
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
Actively Recruiting
3
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
Actively Recruiting
4
Meander Medisch Centrum
Amersfoort, Netherlands
Actively Recruiting
5
Gelre ziekenhuis
Apeldoorn, Netherlands
Actively Recruiting
6
Rijnstate
Arnhem, Netherlands
Actively Recruiting
7
Amphia Ziekenhuis
Breda, Netherlands
Actively Recruiting
8
Deventer Ziekenhuis
Deventer, Netherlands
Actively Recruiting
9
Albert Schweitzer
Dordrecht, Netherlands
Actively Recruiting
10
Catharina ziekenhuis
Eindhoven, Netherlands
Actively Recruiting
11
Maxima MC
Eindhoven, Netherlands
Actively Recruiting
12
Treant
Emmen, Netherlands
Actively Recruiting
13
UMCG
Groningen, Netherlands
Actively Recruiting
14
Spaarne Gasthuis
Haarlem, Netherlands
Actively Recruiting
15
Tergooi MC
Hilversum, Netherlands
Actively Recruiting
16
Medisch Centrum Leeuwarden
Leeuwarden, Netherlands
Actively Recruiting
17
Maastricht UMC
Maastricht, Netherlands
Actively Recruiting
18
St Antonius Ziekenhuis
Nieuwegein, Netherlands
Actively Recruiting
19
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Actively Recruiting
20
Bravis ziekenhuis
Roosendaal, Netherlands
Actively Recruiting
21
Erasmus MC
Rotterdam, Netherlands
Actively Recruiting
22
Maasstad ziekenhuis
Rotterdam, Netherlands
Actively Recruiting
23
St. Franciscus ziekenhuis
Rotterdam, Netherlands
Actively Recruiting
24
Haaglanden Medisch Centrum
The Hague, Netherlands
Actively Recruiting
25
UMC Utrecht
Utrecht, Netherlands
Actively Recruiting
26
Viecuri
Venray, Netherlands
Actively Recruiting
27
Isala
Zwolle, Netherlands
Actively Recruiting
H
Hilin Yildirim, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Hilin Yildirim, Christiaan V Widdershoven, Maureen Jb Aarts...
https://pubmed.ncbi.nlm.nih.gov/37434119