Actively Recruiting
Study of New Blood Biomarkers in Non-IgE Immediate Allergic Reactions to Intravenous Vancomycin in Healthy Adults
Led by Johns Hopkins University · Updated on 2026-08-05
25
Participants Needed
1
Research Sites
4 weeks
Total Duration
AI-Summary
What this Trial Is About
This clinical trial aims to investigate biomarkers involved in non-IgE-mediated immediate hypersensitivity reactions during intravenous vancomycin infusion. The study focuses on identifying new blood biomarkers that appear during these infusion reactions, which can help understand allergic responses to vancomycin. Healthy adult volunteers are the participants in this research conducted by Johns Hopkins University. Participants will receive a single infusion of intravenous vancomycin. Before the infusion, allergy skin testing for vancomycin will be performed to assess sensitivity. This study involves monitoring participants during and after the infusion to detect any hypersensitivity reactions and collect relevant biomarker data. During the trial, participants will undergo blood tests to measure serum vancomycin concentration about 30 minutes after infusion starts. Researchers will also monitor allergy responses and collect biomarker samples. Safety is closely observed, and participants will be required to meet specific health criteria before joining. The total duration of participation varies but includes screening, the infusion visit, and follow-up assessments as needed.
CONDITIONS
Brief Title
Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions
Research Team
J
Jennifer Hoffmann
P
Pooja Akoijam
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