Actively Recruiting
Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation
Led by Istituto Auxologico Italiano · Updated on 2025-09-17
36
Participants Needed
1
Research Sites
190 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called "mirror-PAS"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction. Participants will perform the standard PAS targeting the motor system and the recently developed mirror-PAS in two separate sessions. The investigators will compare the possible effect of the protocols in terms of neurophysiological and behavioral outcomes to identify the optimal PAS method to enhance plasticity and promote sensory-motor function.
CONDITIONS
Official Title
Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 85 years for stroke patients
- Single, unilateral hemispheric stroke confirmed by CT or MRI
- Stroke occurred at least 4 months before enrollment
- Hemiparesis or hemianesthesia of the upper limb caused by stroke
- Age from 18 to 90 years for phantom limb pain patients
- Upper limb amputation at least 2 months before enrollment
- Stable phantom limb pain for at least 2 months before enrollment
You will not qualify if you...
- Any contraindications to transcranial magnetic stimulation (TMS)
- Other neurological diseases such as Parkinson's Disease, Multiple Sclerosis, or ALS
- Orthopedic conditions affecting the hand, such as carpal tunnel syndrome
- Other neurological, orthopedic, or psychiatric conditions for phantom limb pain patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Istituto Auxologico Italiano IRCCS
Milan, Lombardy, Italy, 20122
Actively Recruiting
Research Team
N
Nadia Bolognini, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
OTHER
Number of Arms
2
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