Actively Recruiting
A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)
Led by Incyte Corporation · Updated on 2026-03-24
1500
Participants Needed
32
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective observational study to collect information from adults who have recently undergone an allogeneic stem cell transplant (alloSCT) and are at risk of developing chronic graft-versus-host disease (cGVHD). The study aims to understand the overall burden and severity of cGVHD and explore related healthcare resource use and biological changes over time. Participants in this study are adults aged 18 years or older who had an alloSCT between 90 and 180 days before enrolling. This is a non-interventional study, meaning no treatments are given as part of the research. Instead, participants are observed and data is collected over a period of up to 36 months to monitor their condition and related biological markers. During the study, participants will complete assessment questionnaires either independently or with some assistance. Researchers will collect blood, serum, and saliva samples to analyze changes in proteomic, cytologic, and molecular profiles. The main outcomes measured include the diagnosis and severity of cGVHD, use of personal and healthcare resources, and biological changes related to the disease. The study lasts up to three years, with ongoing monitoring and data collection throughout this time.
CONDITIONS
Brief Title
Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years inclusive at the time of signing the informed consent form
- Allogeneic stem cell transplant 90 to 180 days prior to enrollment
- Able to understand and willing to provide informed consent
- Willing and able to complete participant-assessment questionnaires alone or with minimal assistance
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 36 months
Participants are observed over time to monitor the development and severity of chronic graft-versus-host disease and associated changes.
Periodic visits for assessments and sample collections up to 36 months
Trial Site Locations
Total: 32 locations
1
University of Alabama Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Mayo Clinic Arizona
Phoenix, Arizona, United States, 85054
Actively Recruiting
3
City of Hope
Duarte, California, United States, 91010
Actively Recruiting
4
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
5
University of Colorado
Aurora, Colorado, United States, 80309
Actively Recruiting
6
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224
Actively Recruiting
7
AdventHealth Orlando
Orlando, Florida, United States, 32803
Actively Recruiting
8
Moffit Cancer Center
Orlando, Florida, United States, 33612
Actively Recruiting
9
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
10
Georgia Cancer Center
Augusta, Georgia, United States, 30912
Actively Recruiting
11
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
12
Rush University Medical Group
Chicago, Illinois, United States, 60612
Actively Recruiting
13
The University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
14
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
15
The University of Kansas Clinical Research Center
Fairway, Kansas, United States, 66205
Actively Recruiting
16
Tulane Cancer Center
New Orleans, Louisiana, United States, 70112
Completed
17
University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
18
Massachusetts Cancer Research Center
Boston, Massachusetts, United States, 02114
Actively Recruiting
19
Corewell Health
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
20
Mayo Clinic Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
21
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08602
Actively Recruiting
22
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10021
Actively Recruiting
23
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
24
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
25
The Ohio State University
Columbus, Ohio, United States, 43201
Actively Recruiting
26
Oregon Health Sciences University
Portland, Oregon, United States, 97239
Actively Recruiting
27
Geisinger Health Systems
Danville, Pennsylvania, United States, 17822
Actively Recruiting
28
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
29
Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States, 75246
Actively Recruiting
30
University of Utah, Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
Actively Recruiting
31
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109
Actively Recruiting
32
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
I
Incyte Corporation Call Center (US)
I
Incyte Corporation Call Center (ex-US)
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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