Study of Brain Structure and Function Networks in Children and Adults With Epilepsy

What this Trial Is About

This research investigates epilepsy by studying how the brains structural and functional networks relate to the condition. It focuses on understanding the epileptogenic network, which is a complex brain network involved in generating seizures, rather than just a single epileptogenic zone. Researchers aim to explore how these brain networks differ in people with epilepsy compared to healthy individuals and how these differences may impact cognitive functions. Participants will undergo diagnostic tests including the reconstruction of brain connections from EEG and MRI data. The study observes resting state EEG and MRI scans to analyze functional and structural brain networks. This observational study uses noninvasive methods and simulative models based on routine MRI scans to identify and validate hypotheses about the epileptogenic network. During the study, participants will have their brain connectivity measured once at recruitment to identify regional changes in functional connectivity and to assess the spread of the epileptogenic network. They will also participate in neuropsychological assessments. The study runs from June 2023 to December 2026 and includes patients aged 6 to 65 years with epilepsy, with no active treatment changes involved.

Observational Study of the Structural-functional Connectome in Patients With Epilepsy