Actively Recruiting
One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2026-05-06
100
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
By detailed sequence analysis and subsequent biophysical characterization of prototypic light chains, this project aims to identify sequence fingerprints in IGLV1-44 light chains leading to AL amyloidosis and POEMS syndrome. This understanding might help improve the risk stratification and early diagnosis of patients overexpressing pathologic IGLV1-44 LCs. Moreover, the development of nanobodies efficient in recognizing and stabilizing IGLV1-44 light chains which exert direct toxicity in cardiac AL amyloidosis and POEMS syndrome might form the basis for future development of therapeutic agents capable of counteracting IGLV1-44 light chain proteotoxicity.
CONDITIONS
Official Title
One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy-proven diagnosis of systemic AL amyloidosis, POEMS syndrome or multiple myeloma
- Planned peripheral blood sampling with or without bone marrow aspiration
- Age over 18 years
- Willingness to allow use of clinical data and leftover diagnostic specimens for research by signing informed consent
You will not qualify if you...
- Undefined monoclonal gammopathy or non-AL amyloidosis
- Patients meeting criteria for complete hematologic response after anti-clonal therapy
- Age under 18 years
- Unwillingness to allow use of clinical data and leftover diagnostic specimens for research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
Research Team
M
Mario Nuvolone, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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