Actively Recruiting
Cerebral Hemodynamics and Cerebrospinal Fluid Dynamics in Postdural Puncture Headache An MRI Study for Exploring the Pathophysiological Mechanisms and Implication of Treatment
Led by Umeå University · Updated on 2024-02-12
160
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
Umeå University
Lead Sponsor
R
Region Västerbotten
Collaborating Sponsor
AI-Summary
What this Trial Is About
Post dural puncture headache (PDPH) is a common serious complication that can happen after a lumbar puncture or accidental dural puncture, especially in women receiving epidural analgesia during labor. This condition causes significant distress, particularly for new mothers, and affects their emotional bonding with their newborns. Researchers are evaluating changes in brain and cerebrospinal fluid (CSF) dynamics using advanced MRI to better understand the causes and mechanisms behind PDPH. The study involves two groups: one with patients aged 20 to 40 undergoing planned neurological evaluation including lumbar puncture, with 40 subjects who develop PDPH and 40 who do not; the other group includes parturients who had epidural analgesia, with 40 subjects experiencing accidental dural puncture with PDPH and 40 without. All participants will undergo MRI examinations to assess cerebral blood flow, CSF volume, and pulsation. Participants will be monitored with MRI after 3 months to measure changes in cerebral dynamics. The study aims to quantify how dural puncture affects brain blood flow and CSF movement. This information may lead to improved management of PDPH. The total involvement includes MRI scans and clinical assessments related to headache symptoms and brain fluid dynamics.
CONDITIONS
Brief Title
Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postural puncture headache
- Age 20-40 years
You will not qualify if you...
- Other central neurological disorders except postural puncture headache
- Acute medical condition
- Pregnancy
- Pacemaker or other medical implants not compatible with MRI
- Invasive procedures on the central nervous system or spine/brain surgery in the last 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day assessment
Participants undergo MRI examinations to assess cerebral blood flow and cerebrospinal fluid dynamics related to postural puncture headache.
1 visit (in-person)
Duration - 3 months
Participants are monitored for changes in cerebral dynamics over 3 months following MRI assessment.
No scheduled visits; observational follow-up
Trial Site Locations
Total: 1 location
1
Umeå University Hospital
Umeå, Västerbotten County, Sweden
Actively Recruiting
Research Team
E
Erik Burman, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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