Study of Biomarkers in Patients with HPV-Associated Oropharynx Squamous Cell Carcinoma Collecting Tissue and Blood Samples to Improve Clinical Care

What this Trial Is About

Researchers are conducting a prospective pilot observational study focused on patients with squamous cell carcinoma of the oropharynx OPSCC linked to human papillomavirus HPV. The study aims to discover predictive biomarkers that can guide clinical care by analyzing biological and radiological data. Important goals include understanding the levels of circulating HPV-DNA and immune system responses in these patients. Participants will provide tissue samples and blood to detect HPV-DNARNA and to perform immune cell analysis, study extracellular vesicles, and measure cytokines and chemokines involved in immune responses. Radiological images will be collected during diagnosis and treatment for research purposes but will not influence patient care decisions. No genomic or protein molecular analyses will be performed. Throughout the study, researchers will monitor HPV-DNA levels circulating in blood over 24 months and study immune cells and extracellular vesicles during this time. The study will follow patients from diagnosis through their care pathway, ensuring detailed data collection without affecting treatment. This allows for a comprehensive understanding of HPV-associated OPSCC and supports future improvements in managing this cancer.

Patients With Human Papillomavirus-associated Head and Neck Cancer for the Discovery of Predictive Biomarkers to Guide Clinical Intervention