Actively Recruiting
Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression
Led by University of Calgary · Updated on 2026-05-14
452
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a parallel arm randomized (1:1) controlled trial. Adolescents aged 12-17 years (n=452) who are starting or changing a selective serotonin reuptake inhibitor (SSRI) for depression and/or anxiety will be randomly allocated to receive 12-weeks of pharmacogenetic-guided antidepressant therapy (experimental intervention) or current prescribing guidelines/recommendations guided therapy (control intervention).
CONDITIONS
Official Title
Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 12 to 17 years
- Primary concern of depression and/or anxiety confirmed by treating physician
- Intend to start a new SSRI medication
- Ability to understand and speak English
You will not qualify if you...
- Diagnosis of obsessive compulsive disorder, psychosis, bipolar disorder, eating disorder, autism spectrum disorder, fetal alcohol spectrum disorder, or intellectual disability
- History of non-response to three or more SSRI medications as confirmed by treating physician
- Brain stimulation therapy started within 8 weeks before referral or planned change/initiation during study
- History of liver or hematopoietic cell transplant
- Previous testing for CYP2B6, CYP2C19, or CYP2D6 genetic variants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Calgary
Calgary, Alberta, Canada, T2N 4N1
Actively Recruiting
Research Team
M
Meagan Shields, BSc., MSc.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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