Actively Recruiting
A Pilot Study to Correlate 4-18F- Fluoro-1-naphthol 18F-4FN PET/CT Imaging With Chronic Graft Versus Host Disease Manifestations
Led by M.D. Anderson Cancer Center · Updated on 2026-04-16
16
Participants Needed
1
Research Sites
215 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To study the safety and possible side effects of using the imaging agent 4-\[18F\]Fluoro-1-Naphthol (also called \[18F\]4FN) in PET/CT scans for participants with chronic GVHD.
CONDITIONS
Official Title
A Pilot Study to Correlate 4-18F- Fluoro-1-naphthol 18F-4FN PET/CT Imaging With Chronic Graft Versus Host Disease Manifestations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with chronic GVHD affecting joints with limitation of range of motion
- Able to give written informed consent
- Creatinine clearance of 30 mL/min/1.73m2 or higher
- May have other non-joint chronic GVHD features
- May be planned to receive or currently receiving systemic therapy for chronic GVHD
- ECOG performance status of 0, 1, or 2
- Willingness and ability to use adequate contraception during study participation if of child-bearing potential
You will not qualify if you...
- Unable to comply with all study procedures
- Pregnant or lactating women
- Known allergy or contraindication to [18F]4FN
- Body weight 400 pounds or more or body size preventing entry into PET/CT scanner
- Any other serious medical condition or illness that may interfere with study participation
- Children under 18 years of age
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
G
George L Chen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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