Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT03573089

Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

Led by The University of Queensland · Updated on 2025-07-01

3600

Participants Needed

115

Research Sites

472 weeks

Total Duration

On this page

Sponsors

T

The University of Queensland

Lead Sponsor

N

National Health and Medical Research Council, Australia

Collaborating Sponsor

AI-Summary

What this Trial Is About

During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.

CONDITIONS

Official Title

Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 45 years or older, or age 18 years or older with diabetes
  • End-stage kidney disease on haemodialysis or peritoneal dialysis for at least 3 months
  • Currently prescribed at least one phosphate-lowering medication at any dose
  • Able to provide informed consent
Not Eligible

You will not qualify if you...

  • Scheduled for elective kidney transplantation
  • Major illness expected to cause death within 6 months as judged by the treating physician
  • Participation in an interventional study likely to affect serum phosphate concentration

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 115 locations

1

Royal Prince Alfred Hosptial

Camperdown, New South Wales, Australia, 2050

Active, Not Recruiting

2

Nepean Hospital

Kingswood, New South Wales, Australia, 2750

Active, Not Recruiting

3

St George Hospital

Kogarah, New South Wales, Australia, 2217

Active, Not Recruiting

4

Royal North Shore Hospital

Saint Leonards, New South Wales, Australia, 2065

Active, Not Recruiting

5

Western Sydney Renal Service

Westmead, New South Wales, Australia, 2145

Active, Not Recruiting

6

Wollongong Hospital

Wollongong, New South Wales, Australia, 2500

Active, Not Recruiting

7

Sunshine Coast University Hospital

Birtinya, Queensland, Australia, 4575

Active, Not Recruiting

8

Royal Brisbane and Women's Hospital

Brisbane, Queensland, Australia, 4006

Active, Not Recruiting

9

Princess Alexandra Hospital

Brisbane, Queensland, Australia, 4110

Active, Not Recruiting

10

Bundaberg Hospital

Bundaberg, Queensland, Australia, 4670

Active, Not Recruiting

11

Cairns Hospital

Cairns, Queensland, Australia, 4870

Active, Not Recruiting

12

Fraser Coast Renal Service

Hervey Bay, Queensland, Australia, 4655

Active, Not Recruiting

13

Mackay Hospital

Mackay, Queensland, Australia, 4740

Active, Not Recruiting

14

Logan Hospital

Meadowbrook, Queensland, Australia, 4131

Active, Not Recruiting

15

Gold Coast University Hospital

Southport, Queensland, Australia, 4215

Active, Not Recruiting

16

Townsville University Hospital

Townsville, Queensland, Australia, 4817

Active, Not Recruiting

17

Central and Northern Adelaide Renal and Transplant Service

Adelaide, South Australia, Australia, 5000

Active, Not Recruiting

18

Flinders Medical Centre

Bedford Park, South Australia, Australia, 5042

Active, Not Recruiting

19

Austin Health

Heidelberg, Victoria, Australia, 3084

Active, Not Recruiting

20

Royal Melbourne Hospital

Melbourne, Victoria, Australia, 3050

Active, Not Recruiting

21

St Vincent's Hospital Melbourne

Melbourne, Victoria, Australia, 3065

Active, Not Recruiting

22

Latrobe Regional Hospital

Traralgon, Victoria, Australia, 3844

Active, Not Recruiting

23

Armadale Hospital

Armadale, Washington, Australia, 6112

Active, Not Recruiting

24

BRA Santa Casa de Misericórdia de Ponta Grossa

Ponta Grossa, Paraná, Brazil, 84010-200

Actively Recruiting

25

Sociedade Hospitalar Angelina Caron

Campina Grande, Paraíba, Brazil, 58407-350

Actively Recruiting

26

Hospital de Clinicas Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Actively Recruiting

27

Fundacao Felice Rosso - Hospital Felicio Rocho

Barro Preto, Brazil

Actively Recruiting

28

Hospital Alemao Oswaldo Cruz

São Paulo, Brazil

Actively Recruiting

29

Foothills Hospital/ U of Calgary

Calgary, Alberta, Canada, T2N 4Z6

Actively Recruiting

30

Alberta Health Services

Edmonton, Alberta, Canada

Actively Recruiting

31

St. Paul's Hospital

Vancouver, British Columbia, Canada, V6Z 1Y6

Actively Recruiting

32

Vancouver General Hospital

Vancouver, British Columbia, Canada

Completed

33

Dalhousie University

Halifax, Nova Scotia, Canada, B3H 4R2

Actively Recruiting

34

Queen's University

Kingston, Ontario, Canada, K7L 3N6

Actively Recruiting

35

London Health Sciences Centre

London, Ontario, Canada, N6A 5W9

Actively Recruiting

36

Oakville Trafalgar Memorial Hospital

Oakville, Ontario, Canada, L6M 0L8

Actively Recruiting

37

Orillia Soldier's Memorial Hospital

Orillia, Ontario, Canada

Actively Recruiting

38

Lakeridge Health

Oshawa, Ontario, Canada, L1G 2B9

Actively Recruiting

39

The Ottawa Hospital

Ottawa, Ontario, Canada, K1H 8L6

Actively Recruiting

40

Mackenzie Health

Richmond Hill, Ontario, Canada

Actively Recruiting

41

Scarborough Hospital Network

Scarborough Village, Ontario, Canada, M1P 2V5

Actively Recruiting

42

St Michael's Hospital

Toronto, Ontario, Canada, M5B 1W8

Actively Recruiting

43

University Health Network - University of Toronto

Toronto, Ontario, Canada, M5G 1L7

Actively Recruiting

44

St. Joseph's Healthcare Hamilton

Toronto, Ontario, Canada, M6R 1B5

Actively Recruiting

45

St. Joseph's Healthcare Toronto

Toronto, Ontario, Canada, M6R 1B5

Actively Recruiting

46

The Charles Lemoyne Hospital

Longueuil, Quebec, Canada

Actively Recruiting

47

McGill University Health Centre

Montreal, Quebec, Canada, 4A 3J1

Actively Recruiting

48

Hopital Maisonneuve Rosemont

Montreal, Quebec, Canada, H1T 2M4

Actively Recruiting

49

CHUM

Montreal, Quebec, Canada, H2W 1T8

Actively Recruiting

50

Jewish General Hospital

Montreal, Quebec, Canada, H3T 1E2

Actively Recruiting

51

Sacre Coeur Hospital

Montreal, Quebec, Canada, H4J 1C5

Actively Recruiting

52

CHU de Quebec Universite Laval

Québec, Quebec, Canada, G1V 4G2

Actively Recruiting

53

Centre hospitalier universitaire de Sherbrooke (CHUS)

Sherbrooke, Quebec, Canada, J1H 5N4

Actively Recruiting

54

Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, Canada

Actively Recruiting

55

Red Deer Hospital;

Red Deer, Canada

Actively Recruiting

56

Humber River Hospital

Toronto, Canada

Actively Recruiting

57

Michael Garron Hospital

Toronto, Canada

Actively Recruiting

58

Trillium Health Partners

Toronto, Canada

Actively Recruiting

59

AURA Paris Plaisance

Paris, France

Actively Recruiting

60

Hadassah University

Jerusalem, Israel

Actively Recruiting

61

Shaare Zedek Medical Centre

Jerusalem, Israel

Actively Recruiting

62

Meir Hospital

Kfar Saba, Israel

Actively Recruiting

63

Sheba Hospital

Ramat Gan, Israel

Actively Recruiting

64

Auckland City Hospital

Auckland, New Zealand

Completed

65

Christchurch Hospital

Christchurch, New Zealand

Completed

66

Dunedin Hospital

Dunedin, New Zealand

Completed

67

Waikato DHB

Hamilton, New Zealand

Completed

68

Hawkes Bay Hospital

Hastings, New Zealand

Completed

69

Middlemore Hospital

Otahuhu, New Zealand

Completed

70

Waitematā Hospital

Takapuna, New Zealand

Completed

71

Northland DHB

Whangarei, New Zealand

Completed

72

Ramathibodi Hospital

Bangkok, Khet Ratchathewi, Thailand, 10400

Actively Recruiting

73

Cambridge University Hospitals NHS Foundation Trust

Cambridge, Cambridgeshire, United Kingdom

Actively Recruiting

74

University Hospitals Plymouth NHS Trust

Plymouth, Devon, United Kingdom

Actively Recruiting

75

Dorset County Hospital NHS Foundation Trust

Dorchester, Dorset, United Kingdom

Actively Recruiting

76

South Tyneside And Sunderland NHS Foundation Trust

Sunderland, Durham, United Kingdom

Actively Recruiting

77

East and North Hertfordshire NHS Trust

Stevenage, Hertfordshire, United Kingdom

Actively Recruiting

78

East Kent Hospitals University NHS Foundation Trust

Canterbury, Kent, United Kingdom

Actively Recruiting

79

NHS Greater Glasgow and Clyde

Glasgow, Kent, United Kingdom

Actively Recruiting

80

James Paget University Hospitals NHS Foundation Trust

Great Yarmouth, Norfolk, United Kingdom

Actively Recruiting

81

NHS Lanarkshire

Airdrie, North Lanarkshire, United Kingdom

Actively Recruiting

82

South Tees Hospitals NHS Foundation Trust

Middlesbrough, North Yorkshire, United Kingdom

Actively Recruiting

83

York and Scarborough Teaching Hospitals NHS Foundation Trust

York, North Yorkshire, United Kingdom

Actively Recruiting

84

Nottingham University Hospitals NHS Trust

Nottingham, Nottinghamshire, United Kingdom

Actively Recruiting

85

NHS Highland

Inverness, Scotland, United Kingdom

Actively Recruiting

86

Shrewsbury and Telford Hospital NHS Trust

Shrewsbury, Shropshire, United Kingdom

Actively Recruiting

87

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, South Yorkshire, United Kingdom

Actively Recruiting

88

University Hospital of North Midlands NHS Trust

Stoke-on-Trent, Staffordshire, United Kingdom

Actively Recruiting

89

West Suffolk Hospital

Bury St Edmunds, Suffolk, United Kingdom

Actively Recruiting

90

University Hospitals Sussex NHS Foundation Trust

Brighton, Sussex, United Kingdom

Actively Recruiting

91

Bradford Teaching Hospital NHS Foundation Trust

Bradford, West Yorkshire, United Kingdom

Actively Recruiting

92

Wirral University Teaching Hospital NHS Foundation Trust

Birkenhead, Wirral, United Kingdom

Actively Recruiting

93

University Hospital Birmingham NHS foundation Trust

Birmingham, United Kingdom

Actively Recruiting

94

Cardiff and Wales University Local Health Board

Cardiff, United Kingdom

Actively Recruiting

95

North Cumbria Integrated Care NHS Foundation Trust

Carlisle, United Kingdom

Actively Recruiting

96

Epsom and St Helier University Hospitals NHS Trust

Carshalton, United Kingdom

Actively Recruiting

97

Gloucestershire Hospital NHS Foundation Trust

Cheltenham, United Kingdom

Actively Recruiting

98

University Hospitals Coventry & Warwickshire

Coventry, United Kingdom

Actively Recruiting

99

University Hospitals of Derby and Burton

Derby, United Kingdom

Actively Recruiting

100

Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust

Doncaster, United Kingdom

Actively Recruiting

101

The Dudley Group NHS Foundation Trust

Dudley, United Kingdom

Actively Recruiting

102

Royal Devon and Exeter NHS Foundation Trust

Exeter, United Kingdom

Actively Recruiting

103

Hull University Teaching Hospital NHS Trust

Hull, United Kingdom

Actively Recruiting

104

Ipswich Hospital (East Suffolk & North Essex Foundation Trust)

Ipswich, United Kingdom

Actively Recruiting

105

University Hospitals Of Leicester NHS Trust

Leicester, United Kingdom

Actively Recruiting

106

Royal Liverpool University Hospitals

Liverpool, United Kingdom

Actively Recruiting

107

University Hospital Aintree

Liverpool, United Kingdom

Actively Recruiting

108

Guy's and St Thomas' NHS Foundation Trust

London, United Kingdom

Actively Recruiting

109

King's College Hospital NHS Foundation Trust

London, United Kingdom

Actively Recruiting

110

St George's University Hospitals NHS Foundation Trust

London, United Kingdom

Actively Recruiting

111

Manchester University NHS Foundation Trust

Manchester, United Kingdom

Actively Recruiting

112

The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, United Kingdom

Actively Recruiting

113

Royal Berkshire NHS Foundation Trust

Reading, United Kingdom

Actively Recruiting

114

Mid and South Essex NHS Foundation Trust

Southend-on-Sea, United Kingdom

Actively Recruiting

115

The Royal Wolverhampton NHS Trust

Wolverhampton, United Kingdom

Actively Recruiting

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Research Team

R

Ron Wald

CONTACT

R

Rona Smith

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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