Actively Recruiting
Pre-malignant States to Hematologic Malignancies in Firefighters
Led by Wake Forest University Health Sciences · Updated on 2026-04-16
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
W
Wake Forest University Health Sciences
Lead Sponsor
A
Atrium Health Levine Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand whether firefighters exposed to hazardous compounds have an increased chance of developing premalignant blood conditions that could lead to blood cancers and other health problems. The study focuses on firefighters aged 40 to 49 with at least five years of work experience at the Charlotte Fire Department. It evaluates specific blood changes known as clonal hematopoiesis and monoclonal gammopathy that might indicate early signs of blood-related diseases. Participants will provide blood samples and buccal swabs during a baseline visit to test for clonal hematopoiesis and monoclonal gammopathy using advanced sequencing and blood analysis techniques. Those who consent will also have their samples stored for future research. If abnormalities are found, participants may receive referrals for further diagnosis and standard care follow-up as needed. Throughout the study, participants complete a firefighter history assessment, and their test results are reviewed to identify any premalignant states. The primary outcome is the detection of clonal hematopoiesis within approximately six months after enrollment. Secondary outcomes include monoclonal gammopathy results available in about one week, rates of related diagnoses up to a year later, and baseline survey data. The study involves ongoing monitoring and follow-up per medical guidelines, lasting up to 12 months after lab tests.
CONDITIONS
Brief Title
Pre-malignant States to Hematologic Malignancies in Firefighters
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent and authorize release of personal health information
- Be between 40 and 49 years old at consent
- Be able to understand and follow study procedures for the entire study
- Currently employed by Charlotte Fire Department with at least 5 years of on-the-job experience
You will not qualify if you...
- Have a current diagnosis of any hematologic malignancy or blood cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 week to 6 months for lab results availability
Participants provide blood and buccal swab samples at the Baseline visit for evaluation of clonal hematopoiesis, monoclonal gammopathy, and complete blood count. Additional assessments include completing the Firefighter History Assessment.
1 baseline visit (in-person)
Duration - Up to 12 months after lab results
Participants with abnormal findings may receive clinical referrals for further diagnostic assessments and follow-up per standard care. The study collects follow-up diagnosis information up to 12 months after lab results.
Follow-up visits as per clinical referral and standard care
Trial Site Locations
Total: 1 location
1
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
Research Team
M
Megan Lattanze
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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