Study Evaluating Premalignant Blood Conditions and Risk of Blood Cancers in Firefighters Aged 40 to 49 with 5 Years at Charlotte Fire Department

What this Trial Is About

Researchers are investigating whether exposure to hazardous substances experienced by firefighters increases the chance of developing premalignant blood conditions, which may then raise the risk of blood cancers and other health issues. This study focuses on firefighters aged 40 to 49 who have worked for at least five years at the Charlotte Fire Department, examining the link between their occupational exposure and the development of blood disorders. At the baseline visit, participants will provide blood samples to test for clonal hematopoiesis CHIP, monoclonal gammopathy, and other blood abnormalities using various laboratory methods including next-generation sequencing. Buccal swabs and leftover blood samples may also be collected for future research if participants consent. Participants will complete a Firefighter History Assessment to gather exposure and occupational data. If abnormal findings are detected, participants will be referred for further clinical evaluation and standard care follow-up. During the study, participants will be monitored through lab results and surveys. The primary outcome is the detection of CHIP within about six months from enrollment. Secondary outcomes include identifying monoclonal gammopathy within one week, tracking new diagnoses up to 12 months after lab results, and analyzing baseline survey responses. Participants health will be followed according to usual clinical guidelines, and the study is expected to complete by April 2027.

Pre-malignant States to Hematologic Malignancies in Firefighters