Prediction of Risk of Vascular Structural Damage in Patients With Large Vessel Vasculitis Using PET/MRA Imaging

What this Trial Is About

Large vessel vasculitis (LVV) causes inflammation in large blood vessels, which can lead to severe complications like aneurysm and stroke. Current imaging methods have difficulty detecting vessel wall inflammation, making it hard to decide the best time and type of treatment. This research aims to improve examination methods to better assess disease activity and guide treatment decisions using PET/MRA imaging. The study uses positron emission tomography and magnetic resonance imaging (PET/MRA) to assess vascular wall inflammation in patients with LVV. After initial clinical assessment, lab tests, and PET/MRA scans, clinicians will decide on drug treatments such as glucocorticoids, immunosuppressants, or targeted therapies. Patients will be followed for 12 months, with clinic visits every 1 to 2 months based on their condition, and PET/MRA reassessments at 6 and 12 months. Participants will undergo clinical evaluations, laboratory tests, and PET/MRA scans at the start and during follow-up visits to monitor vascular changes. The main outcome measured is vascular structural progression over 12 months, along with imaging measures like SUV max. The study tracks patient health and disease progression through regular assessments during the one-year period to improve understanding of LVV activity and treatment effects.

Prediction of Risk of Vascular Structural Damage in Patients With Large Vessel Vasculitis (LVV) Based on PET/MRA Image Evaluation System